Avtor/Urednik		Wollina, U; Kaatz, M; Kroenert, C; Schoenlebe, J; Schmalenberg, H; Schreiber, G; Koestler, E; Haroske, G
Naslov		Cutaneous Langerhans cell histiocytosis with subsequent development of haematological malignacies: report of two cases
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 15, št. 2
Leto izdaje		2006
Obseg		str. 79-84
Jezik		eng
Abstrakt		Adult cutaneous Langerhans cell histiocytosis (LCH) is a rare disease. We report two cases illustrating the variability of the clinical presentation and the response to treatment. In both cases a remission was achieved: in one case a partial remission with psoralen plus UVA irradiation (PUVA) and methotrexate plus topical corticosteroid ointment; in the other case by treatment with thalidomide. Despite a therapeutic response, both patients later developed haematological malignancies: a chronic myelo-monocytic leukaemia and an acute lymphatic leukaemia. In conclusion, patients with adult cutaneous LCH should be monitored carefully so that a secondary malignancy is not overlooked.
Deskriptorji		HISTIOCYTOSIS, LANGERHANS-CELL SKIN MANIFESTATIONS