Avtor/Urednik		Kroflič, Božidar; Coer, Andrej; Baudoin, Tomislav; Kalogjera, Livije
Naslov		Topical furosemide versus oral steroid in preoperative management of nasal polyposis
Tip		članek
Vir		Eur Arch Oto-rhino-laryngol
Vol. in št.		Letnik 263, št. 8
Leto izdaje		2006
Obseg		str. 767-71
Jezik		eng
Abstrakt		The efficacy of topical nasal furosemide treatment has been shown in the protection of nasal polyp recurrence. The aim of the study was to compare the effect of oral steroid, as standard preoperative treatment, and inhaled furosemide, as alternative treatment, for 7 days preoperatively in terms os subjective improvement of nasal symptoms, polyp size reduction, inflammation in the polyp tissue, and intraoperative blood loss. A group of 40 patients with nasal polyposis entered the study and they were randomly allocated to 7-day preoperative treatment with either oral methylprednisolon (1 mg/kg/day) or topical furosemide by inhalation (6.6 mmol/l solution). Subjective scores of rhinosinusitis symptoms, polyp scores at endoscopy, and biopsy of the most superficial polyp were taken at inclusion. All procedures were repeated on day 7. Intraoperative blood loss was estimated (scores 0-10) by the surgeon at the operation. Eosinophils, mastocytes, and oedema wer quantified by histomorphometry. Subjective symptoms and endoscopy scores did not differ significantly between the gropus after the treatment although improvement of olfaction was insignificantly better in the steroid group. Steroid treatment significantly reduced eosinophil count, with no effect on mastocytes and oedema. Furosemide treatment did not affect inflammatory cells count significantly, but it has significantly reduced oedema in previously unoperated patients. No difference in intraoperative bleeding was observed between the groups.
Deskriptorji		NASAL POLYPS PREOPERATIVE CARE FUROSEMIDE METHYLPREDNISOLONE EOSINOPHILS