Avtor/Urednik		Strojan, Primož
Naslov		Cysteine cathepsins and their inhibitors in head and neck cancer: an overview of research activities at the Institute of oncology Ljubljana and ENT Department at the Clinical Centre Ljubljana
Prevedeni naslov		Katepsini cisteinske skupine in njihovi inhibitorji pri raku glave in vratu: pregled raziskovalnega dela na Onkološkem inštitutu Ljubljana in Kliniki za otorinolaringologijo Kliničnega centra Ljubljana
Tip		članek
Vir		Radiol Oncol
Vol. in št.		Letnik 40, št. 2
Leto izdaje		2006
Obseg		str. 107-13
Jezik		eng
Abstrakt		To determine the type and extent of the therapy needed for a successful treatment of cancer or to predict clinical outcome, an accurate risk stratification is required. The hypothesis on predictive and prognostic implication of individual cathepsins and their inhibitors originated in their involvement in pericellular proteolysis that participates in virtually all aspects of normal life of a cell and is involved also in the degradation of extracellular matrix barriers during the invasion and metastasizing of tumor cells. The role of cathepsins and their inhibitors in cancer may be categorized as follows: screening markers for diagnosis; predictive markers for lymph node metastasis; predictive markers for response to therapy and for recurrent disease; markers for prognosis. Although the investigations on clinical utility of cathepsins and their endogenous inhibitors in head and neck cancer are limited, the results warranted further evaluation. In the present review, we reported our experience and results gained during a decade of clinically oriented research and made comments on their predictive and prognostic value for routine clinical setting.
Izvleček		Za odličitev o vrsti in intenzivnosti terapije, potrebne za uspešno ozdravitev raka, kot tudi za napoved izida bolezni je potrebna natančna ocena agresivnosti bolezni. Hipoteza, ki predpostavlja napovedni in prognostični pomen posameznih katepsinov in njihovih inhibitorjev, temelji na vpletenosti enih in drugih v obcelične proteolitične procese. Ti so sestavni del večine aktivnosti, povezanih z življenjem normalne celice, kot tudi procesov, povezanih z razgradnjo zunajceličnega matriksa med procesom invazije in zasevanja tumorskih celic. Vlogo katepsinov in njihovih inhibitorjev pri raku lahko razčlenimo na naslednje skupine: markerji za presejanje; markerji za napoved prisotnosti zasevkov v področnih bezgavkah; markerji za napoved odgovora na zdravljenje in ponovitev bolezni; prognostični markerji. Čeprav je raziskav s področja katepsinov in njihovih endogenih inhibitorjev pri raku glave in vratu malo, rezultati opravičujejo nadaljna preučevanja. V pričujočem pregledu smo predstavili naše izkušnje in rezultate iz desetletnega obdobja klinično usmerjenega raziskovalnega dela in podali mnenje o njihovi napovedi in prognostični vlogi za potrebe vsakodnevne klinične prakse.
Deskriptorji		HEAD AND NECK NEOPLASMS CATHEPSINS CYSTEINE PROTEINASE INHIBITORS LYMPHATIC METASTASIS PROGNOSIS IMMUNOHISTOCHEMISTRY DISEASE-FREE SURVIVAL