| Abstrakt | | Thrombophilia is identified as inherited or acquired state of hemostasis with increased risk for arterial or venous thromboembolism. The main causes of inherited thrombophilia are deficiency of antithrombin, protein C, protein S, Factor V Leiden, prothrombin G20210A mutation and hyperhomocystemia. Acquired thrombophilia is a result of diseases or different clinical states as antiphospholipid syndrom, sepsis, major surgery, injuries, immobilisation, disseminated intravascular coagulation, cancer, pregnancy and puerperium, use of oral contraceptives and hormone replacement therapy. In patients younger than fifty, thrombophilia is an important risk factor for thrimboembolism. Patients and methods One month after discontinuation of anticoagulant therapy, 300 patients younger than fifty, with first event or recurrence of venous thromboembolism, were tested for AT, PC, PS, FV Leiden and ProtA20210G mutation. All measurements were performed using automatic analyzer Behring Coagulation System (BCS). Prothrombin mutation and FV Leiden were determined by PCR method in laboratory for medical genetics. Results There were 142 (47.3%) patients with inherited thrombophilic factors, among them 49 (34.5%) men and 93 (65.5%) female. Deficiency of AT was found in 10 (7.0%), PC in 14 (9.8%), PS in 43 (30.3%), FVL in 48 (33.8%), 3 of them homozygous, and ProtA20210G in 29 (20.4%) of patients. Combined thrombophilia were also found, 17 (11,2%) PS in FVLeiden, 3 (2,1%) PS in ProtG20210A, 2 (1,4%) PC in ProtG20210A, 2 (1,4%) FVLeiden in ProtG20210A ter 1 (0,7%) FV Leiden in PC. (Abstract truncated at 2000 characters).
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