Avtor/Urednik		Lokar, Lidija; Urlep-Šalinović, Vera
Naslov		Zapleti preprečevanja in zdravljenja z nizkomolekularnimi heparini - heparin inducirana trombocitopenija - HIT - naše izkušnje
Prevedeni naslov		Complications of prevention and therapeutic treatment with low molecular weight heparins - heparin-induced thrombocytopenia (HIT) - our experience
Tip		članek
Vir		In: Urlep-Šalinović V, editor. Hemostatske motnje. Strokovno srečanje ob 30-letnici hemostaziološke dejavnosti v Splošni bolnišnici Maribor; 2006 maj 26; Maribor. Maribor: Splošna bolnišnica Maribor,
Leto izdaje		2006
Obseg		str. 3-18
Jezik		slo
Abstrakt		Heparin, specially low molecular weight heparin, is a widely used drug for treatment and prophylaxis of thromboembolic diseases. Its use take also risk of serious complications, such as heparin-induced thrombocytopenia (HIT), therefore early recognition of them is very important. Methods: A 70-year-old lady was admitted to orthopedic unit for elective surgery. At the time of admission platelet count was 250 x 10/9/l. Routinely she received prophylactic dose of Fragmin (dalteparin) 5000 anti Xa U s.c. 12 hours before surgery, which was continued every 24 hours. On the fifth postoperative day platelet number fall to 158x10/9/l and on seventh to 22x10/9/l. D-dimer concentration was >8000 mig/l. Fragmin was stopped immediately because of suspicious HIT and a blood sample for detection of HIT antibodies was taken. On the ninth postoperative day pulmonary embolism was confirmed with angio CT. A patient was transferred to the Intensive care unit due to clinical monitoring and anticoagulation with warfarin was introduced. In the next few days patient suffered from thrombosis in right brachial and right femoropopliteal vein. Gangrene of II-V fingers of right hand developed and amputation was necessary. Graduallypatients condition become better, so she was transferred back to orthopedic unit and dischared from hospital with normal platelet count and warfarin therapy with INR in therapeutic range. Conclusion: Although HIT antibodies were not detected, clinical symptoms indicated diagnosis of HIT with thrombosis. Because no direct thrombin inhibitors or danaparoids were available, coumarin therapy was the only possible solution. Angiosonography confirmed only venous and no arterial thrombosis. (Abstract truncated at 2000 characters)
Deskriptorji		THROMBOPHLEBITIS HEPARIN, LOW-MOLECULAR-WEIGHT THROMBOCYTOPENIA AGED