Avtor/Urednik		Ghielmetti, Mascia; Zwicker, M; Villiger, PM; Padovan, E
Naslov		Maturation with P3CSK4 lipopeptide does not impair antigen up-take by human dendritic cells
Tip		članek
Vir		In: Immunology 2004. Collection of free papers presented at the 12th International congress of immunology and 4th annual conference of FOCIS; 2004 Jul 18-23; Montreal. Bologna: Mediamond,
Leto izdaje		2004
Obseg		str. 321-5
Jezik		eng
Abstrakt		Synthetic bacterial lipopeptide analogs could constitute a new class of adjuvants for human. We have previously demonstrated that the P3CSK4 lipopeptide can enhance HLA-I restricted T cell responses. We show here that, in spite of a consistent phenotypic maturation, P3CSK4-treated dendritic cells (DC) can efficiently up-take fluorescent Tetanus Toxoid and dextran beads. In both experimental settings the up-take of exogenous particles increases over time and is comparable to immature DC. Thus, P3CSK4 adjuvant shelters DC functions required for HLA-II restricted antigen presentation.
Deskriptorji		DENDRITIC CELLS HLA-DR ANTIGENS PHENOTYPE ENDOCYTOSIS ADJUVANTS, IMMUNOLOGIC