Avtor/Urednik		Velenšek-Prestor, Veronika
Naslov		Okvara srca po zdravljenju raka v otroštvu
Prevedeni naslov		Cardiac damage after treatment of childhood cancer
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 117
Jezik		slo
Abstrakt		One of the largest risk groups for cardiovascular disease are patients who were treated for cancer in childhood, the injury being related to both irrradiation and chemotherapy. We have determined the frequency of late effects on the heart after childhood cancer treatment in Slovenia and then identified groups at the highest and lowest risk. At the same time we have tried to formulate a protocol for follow-up of late effect on the heart. 211 patients were included in the study. They were treated for childhood cancer 1968 - 1998 at ages of two months to 18 years. All were over 18 years old and at least 5 years after the end of treatment. The observation time was 5 - 32 years, average 16 years. The treatment consisted either alone of surgery, radiation or chemotherapy or combination of two or all mentioned methods. Due to considerable difference in treatment in different time spans, three groups were formed according to the date of treatment: 1968 - 78, 1979 - 88 and 1989 - 98. Fifty-nine patients had been treated surgically, 191 had received chemotherapy, 166 irradiation and in 56 of the latter the heart had been within the field of radiation. The total irradiation dose in the area of the heart was between 10-42 Gy, average 28 Gy. Chemotherapy with anthracyclines had been given to 146 patients, the total dose was 50-620 mg/m2, average 247 mg/m2. Antracyclines and alkylating agents together had been given to 136 patients. Thirty-three children had been treated with anthracyclines and irradiation to the heart area. The cardiological diagnostic methods included history, physical examination, electrocardiogram (ECG), electrocardiographic exercise testing on a bycicle ergometer and echocardiography. Descriptive and univariate analysis (chi square test) as well as multivariate analysis (decision tree) were used for data analysis. (Abstract truncated at 2000 characters)
Deskriptorji		NEOPLASMS HEART HEART DISEASES EXERCISE TEST ELECTROCARDIOGRAPHY PHYSICAL EXAMINATION ECHOCARDIOGRAPHY MULTIVARIATE ANALYSIS