Avtor/Urednik		Čufer, Tanja; Snoj, Nataša
Naslov		Algoritmi zdravljenja raka dojke in novosti na tem področju
Prevedeni naslov		Treatment algorithms for breast cancer and new approaches
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 45, št. Suppl 1
Leto izdaje		2006
Obseg		str. 7-13
Jezik		slo
Abstrakt		The treatment of breast cancer is multidisciplinary and encompasses both local and systemic therapy. Various types of breast cancer can be distinguished: operable breast cancer, locally advanced breast cancer and metastatic breast cancer. Systemic treatment of breast cancer, which includes cytostatic, hormonal and biological therapy, significantly improves chances for cure and breast conserving surgery in operable and locally advanced breast cancer, as well as for prolonged survival with modest quality of life in metastatic disease. Adjuvant chemotherapy and adjuvant hormonal therapy with tamoxifen were found to improve survival rates of early breast cancer patients by more than a half and today over two thirds of patients are already cured. Evidence exists that the incorporation of new drugs, such as taxanes and aromatase inhibitors, will further improve the efficacy of breast cancer treatment. In addition, there are new biological drugs under development and due to already proven high efficacy of trastuzumab, it is expected that biologics will further improve cure rates of breast cancer patients. At this stage, we are moving from the era of empirical oncology to the era of molecular oncology, in which efficient treatments will be based on specific biological characteristics of each individual tumor.
Izvleček		Zdravljenje raka dojke je multidisciplinarno in obsega tako lokalno kot tudi sistemsko zdravljenje. Rak dojke razvrstimo v operabilni rak dojke, lokalno napredovali in razsejani rak. Sistemsko zdravljenje raka dojk, ki obsega citostatsko, hormonsko in v zadnjem času tudi biološko zdravljenje, značilno izboljša možnosti ozdravitve in nudi večje možnosti ohranitvene kirurgije operabilnega in lokalno napredovalega raka dojk, bolnicam z razsejanim rakom dojk pa nudi vedno daljše zazdravitve ob dobri kakovosti življenja. Dopolnilno zdravljenje s citostatiki in hormonskim zdravilom tamoksifen je v zadnjih desetletjih za večkot polovico izboljšalo možnosti ozdravitve lokalno omejenega raka dojk in danes zato ozdravi že več kot dve tretjini bolnic. Prihajajo vedno nova zdravila, kot so taksani, aromatazni inhibitorji, ki bodo izboljšala učinkovitost zdravljenja. Predvsem pa se, na podlagi že dokazane velike učinkovitosti transtuzumaba pričakuje, da bo uvedba še drugih bioloških zdravil, ki so v razvoju, občutno izboljšala možnosti ozdravitve. Iz empirične onkologije prehajamo v dobo molekularne onkologije, kjer bo učinkovito zdravljenje temeljilo na biologiji vsakega posameznega tumorja.
Deskriptorji		BREAST NEOPLASMS NEOPLASM METASTASIS