Avtor/Urednik		Lovrečić, Luca
Naslov		Populacijska analiza Y kromosoma na območju Kočevja in Gorskega Kotarja
Prevedeni naslov		Population analysis of Y chromosome in Kočevje and Gorski Kotar region
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Biotehniška fakulteta
Leto izdaje		2001
Obseg		str. 50
Jezik		slo
Abstrakt		The Kočevje and Gorski Kotar region has a very high prevalence of multiple sclerosis (MS) (190,5/100 000). Two intervals of imigration to Kočevje and Gorski Kotar region are documented from Saxony (Germany) where the prevalence of MS is also high (120/100 000). The aim of this study was to test the hypothesis that the population of Kočevje and Gorski Kotar is isolated and has a higher genetic similarity to the population of Saxony compared to the general Croatian and Slovene population. We analysed 7 Y-chromosomal STR loci in Kočevje and Gorski Kotar region, Slovenia and Croatia. Gene diversities of each locus and haplotype diversities were calculated. The allelic frequency distribution, haplotypes and molecular variance were compared between the analysed populations and the Saxony population. Results indicate isolation and low genetic diversity of the Kočevje and Gorski Kotar population. Haplotype comparison and some of the YSTR loci analyses (DYS392) confirmed higher similarity of the population of Kočevje and Gorski Kotar to the population of Saxony. AMOVA analyses confirmed that most of the total genetic variability between populations is due to variability inside populations (>99 %) and not between them. Analysing isolated populations with low genetic variability and high prevalence of a specific disease is optimal for identifying possible causes of multifactorial diseases like MS. We have defined the first such population in Slovenia and Croatia which has great relevance in the identification of previously unknown possible genetic factors in MS.
Deskriptorji		MULTIPLE SCLEROSIS Y CHROMOSOME HAPLOTYPES ALLELES POLYMORPHISM (GENETICS) PREVALENCE POLYMERASE CHAIN REACTION CROATIA SLOVENIA