Avtor/Urednik		Billiard, M; Bassetti, C; Dauvilliers, Y; Dolenc-Grošelj, L; Lammers, GJ; Mayer, G; Pollmaecher, T; Reading, P; Sonka, K
Naslov		EFNS guidelines on management of narcolepsy
Tip		članek
Vir		Eur J Neurol
Vol. in št.		Letnik 13, št. 10
Leto izdaje		2006
Obseg		str. 1035-48
Jezik		eng
Abstrakt		Management of narcolepsy with or without cataplexy relies on several classes of drugs, namely stimulants for excessive daytime sleepiness and irresistible episodes of sleep, antidepressants for cataplexy and hypnosedative drugs for disturbed nocturnal sleep. In addition, behavioral measures can be of notable value. Guidelines on the management of narcolepsy have already been published. However contemporary guidelines are necessary given the growing use of modafinil to treat excessive daytime sleepiness in Europe within the last 5-10 years, and the decreasing need for amphetamines and amphetamine-like stimulants; the extensive use of new antidepressants in the treatment of cataplexy, apart from consistent randomized placebo-controlled clinical trials; and the present re-emergence of gamma-hydroxybutyrate under the name sodium oxybate, as a treatment of all major symptoms of narcolepsy. A task force composed of the leading specialists of narcolepsy in Europe has been appointed. This task force conducted an extensive review of pharmacological and behavioral trials available in the literature. All trials were analyzed according to their class evidence. Recommendations concerning the treatment of each single symptom of narcolepsy as well as general recommendations were made. Modafinil is the first-line pharmacological treatment of excessive daytime sleepiness and irresistible episodes of sleep in association with behavioral measures. However, based on several large randomized controlled trials showing the activity of sodium oxybate, not only on cataplexy but also on excessive daytime sleepiness and irresistible episodes of sleep, there is a growing practice in the USA to use it for the later indications. (Abstract truncated at 2000 characters.)
Deskriptorji		NARCOLEPSY CATAPLEXY AMPHETAMINES SODIUM OXYBATE METHYLPHENIDATE PEMOLINE MAZINDOL PHENELZINE SELEGILINE CLOMIPRAMINE BENZODIAZEPINES MONOAMINE OXIDASE INHIBITORS PRACTICE GUIDELINES