Avtor/Urednik		Luzar, Boštjan; Gašljević, Gorana; Jurčić, Vesna; Bračko, Matej
Naslov		Hemosiderotic fibrohistiocytic lipomatous lesion: early pleomorphic hyalinizing angiectatic tumor?
Tip		članek
Vir		Pathol Int
Vol. in št.		Letnik 56, št. 5
Leto izdaje		2006
Obseg		str. 283-6
Jezik		eng
Abstrakt		Hemosiderotic fibrohistiocytic lipomatous lesion (HFLL) and early pleomorphic hyalinizing angiectatic tumor (PHAT) are characterized histologically by an admixture of fat, moderately cellular fascicles of hemosiderin-laden spindle cells growing in a perivascular, periadipocytic and septal pattern, as well as the presence of macrophages and chronic inflammatory cells. In contrast to a suggested reactive nature of HFLL, PHAT is regarded as a non-metastasizing tumor of uncertain lineage in the recent World Health Organization classification of soft tissue tumors. Reported herein is the case of a 47-year-old woman with an unencapsulated and irregularly circumscribed recurring lesion in the ankle/foot region that developed following ankle distortion and that fulfills histological criteria for both HFLL and early PHAT. In summary, the present case suggests a reactive over-neoplastic nature of HFLL and confirms profound histological similarities with early PHAT. Until more data become available on the biological potential of HFLL/early PHAT, radical surgical excision and follow up of the patient remains the best treatment option.
Deskriptorji		ANGIOFIBROMA ANKLE HEMOSIDERIN HEMOSIDEROSIS LIPIDS LIPOMA NEOPLASM RECURRENCE, LOCAL SOFT TISSUE NEOPLASMS TREATMENT OUTCOME TUMOR MARKERS, BIOLOGICAL