Avtor/Urednik		Kogoj, Aleš
Naslov		Nevrofiziološki korelati motenj supervizijskega pozornostnega sistema pri bolnikih s shizofrenijo
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 90
Jezik		slo
Abstrakt		Information processing deficits and attention abnormalities are a prominent feature of Supervisory attentional system (SAS) is an appropriate model which provides for these disorders in patients with schizophrenia. At the same time, SAS is a model which could explain electrophysiological responses to frequent and non-frequent stimuli in an auditory target-detection task. The purpose of the present investigation was to explore whether the already described changes in electrophysiological responses relate to the impaired SAS functioning as defined by poor performance on neuropsychological tasks. Methods 37 patients with chronic schizophrenia and 15 healthy controls were included in our study. P300 was elicited with the auditory target-detection task to which randomly occurring distractors were added. SAS was estimated with the Stroop test, a part of the Syndrome Short test, and the Controlled Oral Word Association Test. Groups of patients who performed better on neuropsychological tests were compared to those with poorer performance. Responses to distractors of patients with schizophrenia were compared also to the control subjects. Results Patients with schizophrenia were more likely to miss targets in all conditions. Significantly reduced N100 and P300 amplitudes were found in patients with schizophrenia. N200 amplitudes to all target stimulus categories, but not to distractors, were also reduced. Responses to distractors when compared with responses to targets had significantly reduced amplitudes only in the control subjects. While there was a reduction of N200 amplitudes to distractors in both groups, only the control group showed significant enlargement of N200 amplitude when changing distractor in target stimulus. Patients with schizophrenia who performed better on Stroop Interference task and word fluency test tended to have larger P300 amplitude compared with other patients. (Abstract truncated at 2000 characters)
Deskriptorji		SCHIZOPHRENIA ATTENTION NEUROPSYCHOLOGICAL TESTS EVOKED POTENTIALS, AUDITORY MEMORY, SHORT-TERM EVENT-RELATED POTENTIALS, P300