Avtor/Urednik		Medica, Igor; Kastrin, Andrej; Peterlin, Borut
Naslov		Genetic polymorphisms in vasoactive genes and preeclampsia: a meta-analysis
Tip		članek
Vir		Eur J Obstet, Gynecol, Reprod Biol
Vol. in št.		Letnik 131, št. 2
Leto izdaje		2007
Obseg		str. 115-26
Jezik		eng
Abstrakt		There are controversies in reports on the association of polymorphisms in endothelial nitric oxide synthase, angiotensinogen, angiotensin receptor type 1 and angiotensin-converting enzyme genes with an increased risk of developing preeclampsia. We performed a systematic search of published case‐control studies through the PubMed database up to January 2006, and report the results of a meta-analysis of polymorphisms investigated in more than five studies: Glu298Asp in eNOS gene (9 analyses involving 1055 patients and 1788 controls), Met235Thr in AGT gene (13 analyses involving 1128 patients and 2278 controls), and intron 16 insertion‐deletion polymorphism in ACE gene (10 analyses involving 1121 patients and 1361 controls). Statistically significant associations with preeclampsia were identified for the Met235Thr/AGT polymorphism: OR 1.65 (95% CI 1.19, 2.29) if the polymorphism is considered under the dominant genetic model, and OR 1.54 (95% CI 1.12, 2.11) under the recessive model. For insertion‐deletion/ACE polymorphism, statistical significance was demonstrated when the polymorphism was considered under the recessive model: OR 1.51 (95% CI 1.17, 1.94). No single polymorphism was identified as having a major effect.
Deskriptorji		PRE-ECLAMPSIA POLYMORPHISM (GENETICS) NITRIC-OXIDE SYNTHASE ANGIOTENSINOGEN PEPTIDYL-DIPEPTIDASE A PREGNANCY RECEPTORS, ANGIOTENSIN META-ANALYSIS