Avtor/Urednik		Čemažar, Maja
Naslov		Kemijski karcinogeni
Prevedeni naslov		Chemical carcinogens
Tip		članek
Vir		In: Gašperlin L, Žlender B, editors. Karcinogene in antikarcinogene komponente v živilih. 24. Bitenčevi živilski dnevi; 2006 nov 9-10; Ljubljana. Ljubljana: Biotehniška fakulteta, Oddelek za živilstvo,
Leto izdaje		2006
Obseg		str. 23-31
Jezik		slo
Abstrakt		Chemical carcinogens can have direct action on DNA - genotoxic carcinogens or they can indirectly, without affecting DNA directly, influence the carcinogenesis - nongenotoxic carcinogens. The majority of genotoxic carcinogens require enzymatic bioactivation in order to damage DNA. Genotocix potential of chemical carcinogens is dependent upon genetic polymorphism in carcinogen metabolizing enzymes, defects in DNA repair mechanisms and is influenced by cell proliferation. Combination of exact clinical observation, with carefully designed epidemiological studies, as well as io vitro and in vivo tests is the most productive approach in determinarion of potential carcinogenic agents and consequently the assessment of risk.
Deskriptorji		CARCINOGENS BIOTRANSFORMATION POLYMORPHISM (GENETICS) NEOPLASMS CELL TRANSFORMATION, NEOPLASTIC RISK FACTORS MUTAGENS