Avtor/Urednik		Kores-Plesničar, Blanka; Zalar, Bojan; Breskvar, Katja; Dolžan, Vita
Naslov		The influence of the CYP2D6 polymorphism on psychopathological and extrapyramidal symptoms in the patients on long-term antipsychotic treatment
Tip		članek
Vir		J Psychopharmacol (Oxf)
Vol. in št.		Letnik 20, št. 6
Leto izdaje		2006
Obseg		str. 829-33
Jezik		eng
Abstrakt		Poor response to antipsychotics treatment and extra pyramidal side effects (EPS) are the most challenging problems in the treatment of schizophrenia. Several studies were investigating the impact of polymorphic cytochrome P450 2D6 gene (CYP2D6) on EPS but the results were Conflicting. There are practically no clinical studies of Long-term treatment of schizophrenia and CYP2D6 polymorphism. Our aim was to evaluate the influence of CYP2D6 genotype on psychopathotogical symptoms and the occurrence of EPS in Slovenian outpatients with schizophrenia or schizoaffective disorder in stable remission, receiving long-term maintenance antipsychotic treatment. In total 131 outpatients meeting the DSM IV criteria for schizophrenia or schizoaffective disorder and receiving maintenance therapy with haloperidol, fluphenazine, zudopethixole or risperidone were genotyped for 14 polymorphic CYP2D6 alleles. Psychopathological symptoms were assessed with the Positive and Negative Symptom Scale for Schizophrenia (PANSS). EPS were assessed with the Simpson Angus Scale (SAS), the Barnes Akathisia Scale and the Abnormal Involuntary Movement Scale (AIMS). Six patients (4.6%) were genotyped as poor metabolizers (PMs). PMs scored significantly higher on the negative zubscale for PANSS. There were no statistically significant differences between the group of PMs and the group of patients with at least one functional CYP2D6 allele in view of patients characteristics or any of the items of the AIMS, the SAS or the Barnes Akathisia Scale. CYP2D6 genotype may not be the major factor that determines the susceptibility to antipsychotic-induced EPS in Slovenian patients in stable remission and on maintenance therapy with antipsychotics that are mainly CVP2D6 substrates. However, CYP2D6 genotype might be a factor contributing to the persistent negative symptoms of schizophrenia.
Deskriptorji		SCHIZOPHRENIA LONG-TERM CARE ANTIPSYCHOTIC AGENTS POLYMORPHISM (GENETICS) CYTOCHROME P-450 CYP2D6 GENOTYPE PHENOTYPE BASAL GANGLIA DISEASES ANALYSIS OF VARIANCE