Avtor/Urednik		Zadravec-Zaletel, Lorna
Naslov		Dejavniki tveganja za hipogonadizem po zdravljenju raka v otroštvu
Prevedeni naslov		The risk factors for hypogonadism after childhood cancer treatment
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 96
Jezik		slo
Abstrakt		The survival of children with cancer has improved markedly in the last decades.The treatment of childhood cancer may leave cosequences on different organs and organ systems, thus also on gonads.The life expectancy of these young patients being long, research has focussed on the late effects of childhood cancer treatment in the last years.The aim of our study was to evaluate the incidence of hypogonadism within the population of youngsters, treated for childhood cancer in Slovenia 1965-1995 and cured, as well as risk factors for hypogonadism in them. Population and methods: 297 youngsters were included, 115 females and 182 males.They were 0-16 years of age at the diagnosis of malignancy (median 9 yrs), they had hormone testing at 3-32 (median 11,5) years after completed treatment at ages 14-42 (median 20) years. Treatment included chemotherapy with alkylating agentts (ChT-AA) in 189 (63%) pts, ChT without AA in 53 (18%) pts. Fifty-one (17%) pts had radiation treatment (RT) to the pelvis, 100 (34%) pts had cranial RT. Evaluation of gonadal function included clinical examination and laboratory testing (GnRH-test).To evaluate the risk factors for hypogonadism after treatment for childhood cancer, we used a multivariate analysis model of the classification decision tree which allows simultaneous evaluation of the influence of each independent variable, as well as their interacting on the dependent variable. Results: We found primary hypogonadism (PH) in 76 (26%) youngsters, 62 (34%) males and 14 (12%) females. High incidence (50%) of PH was found in those treated for Hodgkin's disease (HD) or germ cell tumor (GCT). A group of males, treated for HD with ChT was at high risk (72%) for PH as was a group treated with RT to the `Ivis and ChT with AA, 79%. (Abstract truncated at 2000 characters)
Deskriptorji		NEOPLASMS HYPOGONADISM RADIOTHERAPY ANTINEOPLASTIC AGENTS SPERMATOGENESIS ADOLESCENCE LEYDIG CELLS OVARY FSH LH