Avtor/Urednik		Chandra, Ashish; Sheikh, Adnan A; Cerar, Anton; Talbot, Ian C
Naslov		Clinico-pathological aspects of colorectal serrated adenomas
Tip		članek
Vir		World J Gastroenterol
Vol. in št.		Letnik 12, št. 17
Leto izdaje		2006
Obseg		str. 2770-2
Jezik		eng
Abstrakt		Aim: To study the association of colorectal serrated adenomas (SAs) with invasive carcinoma, local recurrence, synchronicity and metachronicity of lesions. Methods: A total of 4,536 polyps from 1,096 patients over an eight-year period (1987-1995) were retrospectively examined. Adenomas showing at least 50% of serrated architecture were called SAs by three reviewing pathologists. Results: Ninety-one (2%) of all polyps were called SAs, which were found in 46 patients. Invasive carcinomas were seen in 3 out of 46 (6.4%) patients, of whom one was a case of familial adenomatous polyposis (FAP). A male preponderance was noted and features of a mild degree of dysplasia were seen in majority (n=75, 83%) of serrated adenomas. Follow-up ranged 1-12 years with a mean time of 5.75 years. Recurrences of SAs were seen in 3 (6.4%) cases, synchronous SAs in 16 (34.8%) cases and metachronous SAs in 9 (19.6%) cases. Conclusion: Invasive carcinoma arising in serrated adenoma is rare, accounting for 2 (4.3%) cases studied in this series.
Deskriptorji		ADENOMA AGED COLORECTAL NEOPLASMS DISEASE PROGRESSION INCIDENCE NEOPLASM INVASIVENESS NEOPLASM RECURRENCE, LOCAL RETROSPECTIVE STUDIES