Avtor/Urednik		Kirbiš, Simona
Naslov		Vpliv lokalnega vnetnega dogajanja v koronarni arteriji na stabilnost aterosklerotičnih plakov
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 57
Jezik		slo
Abstrakt		Objective. Atherosclerosis is an inflammatory disease. Inflammation plays an important role in atherosclerosis, from initiation, to progression and, eventually plaque rupture resulting in acute coronary syndromes. Patients with acute myocardial infarction have evidence of systemic inflammation, as reflected by elevated levels of interleukins (interleukin-6, interleukin-8, interleukin-10), C - reactive protein and some other inflammatory mediators. However little is known about the cardiac or systemic origin of these markers of inflammation. It was the aim of this study to examine the role of inflammatory markers, interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), high sensitive C - reactive protein (hsCRP), myeloperoxidase (MPO) and soluble receptor of interleukin-2 (tR IL-2) in acute coronary syndrome and to determine their origin. Method. Blood samples were taken from patients with acute coronary syndromes with proven atherosclerotic lesions) of the left or right coronary artery (n=11) at the culprit lesion and from stable angina (n=10) and control (n=9) patients within the left and right coronary artery. Blood was taken from the femoral vein and femoral artery from all patients. Then levels of hsCRP, IL-6, IL-8, IL-10, tR IL-2 and MPO were determined. Results. Levels of hsCRP and IL-10 at the culprit lesion were significantly higher in patients with acute myocardial infarction as compared to the stable angina and control group. Levels of all tested inflammatory markers in peripheral blood did not differ from each other in all groups of patients. There were no statistical differences detectable in the levels of hsCRP, IL-6, IL-8, IL-10, tR IL-2 and MPO in the blood of patients with acute myocardial infarction taken at culprit lesion as compared to the peripheral blood. (Abstract truncated at 2000 characters)
Deskriptorji		MYOCARDIAL INFARCTION CORONARY ARTERIOSCLEROSIS INFLAMMATION MEDIATORS INTERLEUKIN-6 INTERLEUKIN-8 INTERLEUKIN-10 C-REACTIVE PROTEIN ANGINA PECTORIS HEART CATHETERIZATION RECEPTORS, INTERLEUKIN-2 PEROXIDASE