Avtor/Urednik		Medved, Robert
Naslov		Morfometrični in biokemični endometrijski dejavniki, ki vplivajo na ugnezditev zarodka v postopku zunajtelesne oploditve
Prevedeni naslov		Morphometric and biochemical endometrial factors, affecting embryo implantation in in vitro fertilization
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 94
Jezik		slo
Abstrakt		Background: Pregnancy and livebirth rates following in vitro fertilization-embryo transfer (IVF-ET) depend on embryo quality and the number of transferred embryos, but mostly on the mechanisms involved in embryo implantation. The aim of this prospective randomized comparative study was to compare the effect of two different methods of ovarian stimulation in IVF-ET on certain morphometric and biochemical endometrial factors, affecting embryo implantation. Methods: In the study we enrolled 100 randomly selected infertile women. According to the type of ovarian stimulation, they were randomly divided in two groups: 50 women received the gonadotropin releasing hormone (GnRH) antagonist Cetrotide (group C), and 50 the GnRH agonist Suprefact0 (group S). The inclusion criteria were: age < 38 years, normal body weight, regular menstrual cycle, no more than 3 previous failed IVF attempts and the presence of motile sperm after semen preparation. In all enrolled women, IVF-ET and endometrial biopsy during oocyte retrieval were performed. Morphometric (histological endometrial dating, pinopodes) and biochemical (interleukin-1alpha , interleukin-1beta, interleukin-1 receptor antagonist, leukemia inhibiting factor, glycodelin-A and mucin MUCl) factors were determined in endometrial biopsy samples and compared between the groups. Results:Histological endometrial dating (in days) showed advanced maturation in both groups, significantly less advanced in group C (median +l day) than in group S (median + 2 days) (p = 0.025). Pinopodes were found present in 40.9% of women in group C, and in 12.5% of women in group S yielding a significant difference (p = 0.044). (Abstract truncated at 2000 characters)
Deskriptorji		INFERTILITY, FEMALE FERTILIZATION IN VITRO EMBRYO TRANSFER OVULATION INDUCTION ENDOMETRIUM BIOPSY IMMUNOHISTOCHEMISTRY MICROSCOPY, ELECTRON, SCANNING ENZYME-LINKED IMMUNOSORBENT ASSAY PROGESTERONE 17-HYDROXYPROGESTERONE GONADORELIN INTERLEUKIN-1 RECEPTORS, INTERLEUKIN-1 OVUM IMPLANTATION