Avtor/Urednik		Brvar, Miran
Naslov		Protein S100B kot nevrobiokemični označevalec in napovedni parameter pri zastrupitvi z ogljikovim monoksidom
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 66
Jezik		slo
Abstrakt		Carbon monoxide (CO) is the leading cause of poisoning-related death and morbidity in the developed world. It would be convenient to have an objective biochemical marker that would help in the evaluation of severity of CO poisoning and decisions concerning hyperbaricoxygen therapy. The S100B protein is a ealciam-binding protein with a molecular weight of 10.6 kDa. S100B protein is represented in high concentrations in astroglial cells and is released from ischemic astroglial cells into peripheral blood as a result of brain injury and broken blood-brain barrier in CO poisoning. The aim of the study was to assess the possible use of S100B as a biochemical marker and prognostic parameter in CO poisoning that would help us in the evaluarion of severity and decisions concerning hyperbarie-oxygen therapy. In the first part of our research we measured serum S100B levels in CO poisoned patients and correlated it with the clinical picture and outcome of poisoning. CO-poisoned parients who were unconscious on arrival had higher S100B levels compared to those CO-poisoned patients who had only transitory loss of consciousness at the scene. However, CO-poisoned patients with transitory loss of consciousness had higher serum S 100B levels compared to patients without loss of consciousness during CO poisoning. The possible use of S100B as a prognostic parameter in CO poisoning was assessed in an animal model of CO-poisoning due to an insufficient number of CO-poisoned patients included in our study who had neurological sequelae or died. CO poisoning was associated with elevated S100B levels in rats. S100B in CO-poisoned rats was a better predictor of final outcome than the consciousness level, so it could be used as a prognostic parameter for CO poisoning in rats. (Abstract truncated at 2000 characters)
Deskriptorji		CARBON MONOXIDE POISONING PROTEINS PROGNOSIS UNCONSCIOUSNESS DISEASE MODELS, ANIMAL RATS, WISTAR CARBOXYHEMOGLOBIN HYPERBARIC OXYGENATION