Avtor/Urednik		Reich, A; Wrobel, G; Kazanowska, B; Maldyk, J; Bubala, H; Dluzniewska, A; Stefaniak, J; Stefanska, K; Stolarska, M
Naslov		Skin involvement in highly malignant non-Hodgkin lymphomas of childhood and adolescence
Tip		članek
Vir		Acta Dermatovenerol Alp Pannon Adriat
Vol. in št.		Letnik 15, št. 4
Leto izdaje		2006
Obseg		str. 158-68
Jezik		eng
Abstrakt		Objective: The aim of this study was to demonstrate the clinical spectrum of highly malignant cutaneous non-Hodgkin lymphoma (NHL) in children and to define the outcome among these patients. Material and methods: A retrospective analysis of children with NHL treated at Polish oncology centers was carried out in order to determine patients with skin involvement. Thirteen subjects with primary and 4 with secondary cutaneous NHL were studied. The diagnosis of NHL was based on histological and immunohistochemical examination of skin biopsy. Results: Nine of 13 cases of primary cutaneous NHL presented as a tumors. Other manifestations were as follows: hard infiltration, edema of subcutaneous tissue, maculopapular lesions, and generalized erythroderma. The mean time between the first cutaneous symptoms and diagnosis of NHL was 5.6 +_ 3.3 months. Secondary cutaneous lesions during the course of NHL were described as maculopapular or nodular eruption. In addition, 2 subjects had generalized ichthyosis. Among patients with primary cutaneous NHL, 11 (84.6%) subjects are still alive without any signs of the disease. Two children (15.4°/o) died. In patients with secondary skin involvement during the course of NHL only one child is still alive with a residual tumor mass in the mediastinum. The estimated 5-year overall survival for primary cutaneous NHL was significantly better than for individuals with secondary cutaneous NHL (p = 0.02). Conclusions: Primary cutaneous NHL has a relatively favorable prognosis. On the other hand, cutaneous metastases of extracutaneous NHL seem to be a poor prognostic factor.
Deskriptorji		LYMPHOMA, NON-HODGKIN'S SKIN NEOPLASMS SKIN MANIFESTATIONS NEOPLASM STAGING SURVIVAL ANALYSIS RETROSPECTIVE STUDIES