Avtor/Urednik		Bren, Andrej; Kandus, Aljoša
Naslov		Mesto mikofenolata v nefrologiji
Prevedeni naslov		Place of mycophenolate in nephrology
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 45, št. 3
Leto izdaje		2006
Obseg		str. 301-6
Jezik		slo
Abstrakt		The contribution focuses on one of the more recent immunosuppressive drugs, mycophenolate, which is available as mycophenolate mofetil and sodium mycophenolate. The active substance of both compounds is mycophenolic acid. The pharmacodynamics and pharmacokinetics of the active substance are presented. The broadest application of mycophenolate in nephrology is in kidney transplantation, which has resulted in less rejections of kidney grafts and better survival of grafts and patients. Limited success have been obtained in the treatment of some forms of lupus nephritis, systemic vasculitis, membranous nephropathy, focal and segmental glomerulosclerosis and glomerulonephritis with minimal changes, IgA nephropathy and acute interstitial nephritis.
Izvleček		V članku je prikazano novejše imunosupresivno zdravilo mikofenolat, ki je razpoložljivo kot mikofenolat mofetil in natrijeva sol mikofenolne kisline. Zdravilna učinkovina obeh spojin je mikofenolna kislina. Prikazani sta farmakodinamika in farmakokinetika zdravilne učinkovine. V nefrologiji je mikofenolat najpogosteje uporabljan pri presaditvi ledvic, saj omogoča manj zavrnitev, boljše preživetje presadkov in bolnikov. Z omejenimi uspehi se uporablja tudi pri zdravljenju nekaterih oblik lupusnega nefritisa, sistemskih vaskulitisov, membranske nefropatije, fokalne segmentne glomeruloskleroze in glomerulonefritisa z minimalnimi spremembami, IgA-nefropatije in akutnega intersticijskega nefritisa.
Deskriptorji		KIDNEY TRANSPLANTATION KIDNEY DISEASES MYCOPHENOLIC ACID LUPUS NEPHRITIS VASCULITIS GLOMERULONEPHRITIS IMMUNOSUPPRESSIVE AGENTS