Avtor/Urednik		Glišovič, Špela; Glavan, Gordana; Saghafi, Mehdi M; Živin, Marko
Naslov		Upregulation of synaptotagmin IV protein in kainate-induced seizures
Tip		članek
Vir		NEUROREPORT
Vol. in št.		Letnik 18, št. 8
Leto izdaje		2007
Obseg		str. 831-5
Jezik		eng
Abstrakt		Synaptotagmin IV is a product of immediate early-responsegene.lt is involved in the regulated neurosecretion in the brain. Its putative role, however, in vesicular transport and localization in secretory vesicles is still a matterof debate. Here we followed the spatiotemporal pattern of synaptotagmin IV protein upregulation in the hippocampus, caudate putamen, nucleus accumbens, nucleus amygdalae, piriform and entorhinal cortices of rats with kainate-induced seizures. We found that upregulation pattern par alleled the direction of depolarization through the hippocampus and also reflecting seizure activity spreading to other brain regions. We speculate that synaptotagmin IV may have a role in the vesicular transport of the upregulated peptides and proteins involved in the plasticity and/or neurodegeneration provoked by the kainate.
Deskriptorji		SEIZURES KAINIC ACID BRAIN CHEMISTRY IMMUNOHISTOCHEMISTRY DENSITOMETRY SYNAPTOPHYSIN RATS, WISTAR UP-REGULATION (PHYSIOLOGY)