Avtor/Urednik		Logar, Jernej; Žohar-Čretnik, Tjaša; Štorman, Alenka; Premru-Sršen, Tanja; Novak-Antolič, Živa; Arnež, Maja; Kraut, Aleksandra; Stirn-Kranjc, Branka
Naslov		Presejalno testiranje na okužbo s Toxoplasma gondii v nosečnosti
Prevedeni naslov		Screening for Toxoplasma gondii infection in pregnancy
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 45, št. Suppl 3
Leto izdaje		2006
Obseg		str. 17-20
Jezik		slo
Abstrakt		Toxoplasmosis, especially its congenital form caused by parasite Toxoplasma gondii, may cause in women who acquire Toxoplasma infection in pregnancy severe lesions in the fetus or even death of the fetus. Congenital toxoplasmosis can be prevented by informing women how to avoid infection during pregnancy and/or by routine serological screening of pregnant women for a recent Toxoplasma infection. In accordance with our previous results stressing the risk of congenital toxoplasmosis in Slovenia, compulsory screening of pregnant women for Toxoplasma infection was introduced in 1995. The current policy of the Institute of Microbiology and Immunology, Medical Faculty Ljubljana and 7 regional laboratories (Koper, Nova Gorica, Kranj, Novo mesto, Celje, Maribor, Murska Sobota) of Institute Public Health in Slovenia is to screen the sera of susceptible pregnant women for primary Toxoplasma infection by serological tests three times in pregnancy. Pregnant women with confirmed primary T. gondii infection are administered therapy and followed up at the Department of Gynaecology and Obstetrics, University Medical Centre. Serologically IgG and/or IgA positive newborns are treated and followed up at the Department of Infectious Disease and Febrile Illnesses and at the Department of Ophthalmology, University Medical Centre Ljubljana. In the period 1995-2005, to primary Toxoplasma infected women who were screened and treated in time, no child affected by Toxoplasma has been born. Timely sistematical testing, performed repeatedly at least 3 times during pregnancy and clinically long-term monitoring of Toxoplasma infected children is strongly recommended if congenital toxoplasmosis is not to be missed.
Izvleček		Toksoplazmoza, predvsem kongenitalna, ki jo povzroči okužba nosečnice s parazitom Toxoplasma gondii, lahko plod nosečnice hudo poškoduje ali pa povzroči celo njegovo smrt. Kongenitalno toksoplazmozo lahko preprečimo s seznanjanjem nosečnic, kako se tej okužbi lahko izognejo, in/ali s presejalnim testiranjem nosečnic na svežo okužbo s toksoplazmami. Na podlagi naših ugotovitev o nevarnosti in pogostnosti kongenitalne toksoplazmoze v Sloveniji, je bilo obvezno presejalno testiranje nosečnic na toksoplazmozo uvedeno leta 1995. Na Inštitutu za mikrobiologijo in imunologijo Medicinske fakultete v Ljubljani in v sedmih mikrobioloških laboratorijih območnih zavodov za zdravstveno varstvo (Koper, Nova Gorica, Kranj, Novo mesto, Celje, Maribor, Murska Sobota) testiramo na toksoplazmozo serume potencialno ogroženih nosečnic trikrat v nosečnosti. Nosečnice s potrjeno prvo toksoplazemsko okužbo v nosečnosti zdravimo in sledimo na Ginekološki kliniki v Ljubljani. Serološko IgM in/ali IgA pozitivne novorojenčke zdravimo in klinično sledimo na Infekcijski in Očesni kliniki v Ljubljani. Od leta 1995 do konca leta 2005 se nobeni nosečnici, ki je bila pravočasno in sistematično pregledana ter zdravljena, ni rodil otrok, poškodovan zaradi toksoplazmoze. Da kongenitalne toksoplazmoze ne spregledamo, je zelo priporočljivo pravočasno in sistematično serološko testiranje, vsaj trikrat v nosečnosti, in dolgo klinično spremljanje novorojenčkov oz. otrok, okuženih s toksoplazmami.
Deskriptorji		PREGNANCY COMPLICATIONS, INFECTIOUS TOXOPLASMOSIS MASS SCREENING