Avtor/Urednik		Arnež, Maja; Lužnik-Bufon, Tatjana; Pestevšek, Maja; Frelih, Jana; Kraut, Aleksandra; Logar, Jernej; Petrovec, Miroslav; Premru-Sršen, Tanja; Zore, Andrej; Antolič-Novak, Živa
Naslov		Kongenitalna toksoplazmoza v Sloveniji
Prevedeni naslov		Congenital toxoplasmosis in Slovenia
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 45, št. Suppl 3
Leto izdaje		2006
Obseg		str. 153-61
Jezik		slo
Abstrakt		Our aim was to establish how often children, referred to our department because of suspected congenital toxoplasmosis after compulsory screening of pregnant women for toxoplasmosis, are infected with parasite Toxoplasma gondii. Prospective clinical study was conducted at the Department of Infectious Diseases Ljubljana between December 10, 1999 and April 15, 2005. Our patients were children, referred from Slovenian maternity hospitals because of suspected congenital toxoplasmosis. Congenital infection in children was searched for by medical history, physical examination and microbiological investigations. Infected children were treated by anti parasitic drugs. In five years we investigated 397 children with suspected congenital toxoplasmosis. Congenital infection was detected in 13 (4%) of 333 children who remained in the study. In 92% of the children the congenital infection resulted from infection with parasite in mothers in last trimester of pregnancy. Seroconversion of antibodies to Toxoplasma gondii was detected more often in mothers who had given birth to infected children than in mothers, who had given birth to uninfected children. The infection was asyptomatic in 54% of children. In 33% of infected children brain calcifications were found. We could not find any child with ocular toxoplasmosis. A11 children with congenital infection were appropriately treated and the development (so far) is normal. Congenital infection with parasite Toxoplasma gondii was established in 4% of children, referred to our department because of suspected congenital toxoplasmosis after compulsory screening of pregnant women for toxoplasmosis. In 1% of children infection was probable while 95% of children were not infected with parasite.
Izvleček		Ugotoviti smo želeli pogostnost kongenitalne okužbe z zajedalcem Toxoplasmagondii pri otrocih, napotenih na našo kliniko zaradi suma na kongenitalno toksoplazmozo po uvedbi obveznega presejanja v nosečnosti na toksoplazmozo. Prospektivna klinična raziskava je potekala na Kliniki za infekcijske bolezni in vročinska stanja v Ljubljani od 10. decembra 1999 do 15. aprila 2005. Naši preiskovanci so bili otroci, ki so bili napoteni iz siovenskih porodnišnic zaradi suma na kongenitalno toksoplazmozo. Kongenitalno okužbo pri otrocih smo ugotavljali z anamnezo, s kliničnim pregledom in z mikrobiološkimi preiskavami. Okužene otroke smo zdravili s protiparazitnimi zdravili. V petih letih smo obravnavali 397 otrok s sumom na kongenitalno toksoplazmozo. Kongenitalno okužbo smo ugotovili pri 13 (4%) od 333 otrok, ki so ostali v raziskavi. Pri 92% otrok je bila kongenitalna okužba posledica okužbe matere z zajedalcem v zadnjem trimesečju nosečnosti. Matere, ki so rodile okužene otroke, so imele med nosečnostjo pogosteje dokazano serokonverzijo protiteles proti Toxoplasma gondii kot matere, ki so rodile neokužene otroke. Okužbo brez izraženih simptomov je imelo 54% otrok. Pri 33 okuženih otrok smo ugotovili kalcinacije v možganih. Pri nobenem otroku nismo ugotovili očesne toksoplazmoze. Vsi otroci s kongenitalno okužbo so bili ustrezno zdravljeni in se (zaenkrat) razvijajo normalno. Kongenitalno okužbo z zajedalcem Toxoplasma gondii smo ugotovili pri 4% otrok, ki so bili napoteni na našo kliniko zaradi suma na kongenitalno toksoplazmozo po uvedbi obveznega presejanja v nosečnosti na toksoplazmozo. Pri 1% otrok je bila okužba verjetna, medtem ko 95% otrok ni bilo okuženih z zajedalcem.
Deskriptorji		TOXOPLASMOSIS, CONGENITAL TOXOPLASMA SERODIAGNOSIS SLOVENIA