Avtor/Urednik		Kambič, V; Gale, N; Ferluga, D
Naslov		Laryngeal hyperplastic lesions, follow-up study and application of lectins and anticytokeratins for their evaluation
Tip		članek
Vir		Pathol Res Pract
Vol. in št.		Letnik 188, št. 8
Leto izdaje		1992
Obseg		str. 1067-77
Jezik		eng
Abstrakt		A retrospective study of 878 biopsy specimens from 692 patients with laryngeal hyperplastic aberrations was performed according to the Kambič-Lenart classification. Special attention was focused on 88 patients with persistent or recurring disease. In these carcinoma developed in 17 (2.4 per cent ) patients, 12 (1.7 per cent ) of whom had had atypical hyperplasia. We therefore propose that the term precancerosis, which so definitely implies cancer, should be replaced with the expression risky epithelium where nothing is determined in advance, but a careful follow-up of the patients is imperative. In particular cases of laryngeal hyperplastic lesions, mainly in abnormal and in atypical hyperplasias when the tissue specimens are cut tangentially, the exact identification and position of individual epithelial cells is essential. In such cases histochemical and immunohistochemical methods yield more precise evaluation. Lectins and cytokeratins provide good markers of epithelial maturation. These results contribute to a more useful evaluation of laryngeal hyperplastic lesions, crucial for the choice of adequate therapy.
Deskriptorji		LARYNX HYPERPLASIA PRECANCEROUS CONDITIONS HISTOCYTOCHEMISTRY IMMUNOHISTOCHEMISTRY LECTINS FOLLOW-UP STUDIES