Avtor/Urednik		Lorbar, M; Vesnaver, A
Naslov		Citoprotektivni učinek verapramila pri ishemično in hipoksično okvarjenem izoliranem podganjem srcu
Prevedeni naslov		The cytoprotective effect of verapramil on the ischemically and hypoxically injured isolated rat heart
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 31, št. 4
Leto izdaje		1992
Obseg		str. 475-91
Jezik		slo
Abstrakt		Isolated perfused Langendorff rat hearts were used for comparing effects of the calcium antagonist verapamil on the following two models of heart injury: local ischemia (ligature of the anterior interventricular artery) and general hypoxia (perfusate saturated with nitrogen). The degree and extent of injury were assesed by measuring the activity of lactate dehydrogenase in venous effluents from the heart, contractility, heart rate, coronary flow, and ECG. Lactate dehydrogenase activity in the venous effluents was the marker of cellular injury. Verapamil had a beneficial effect on the contractility and rhytmicity after reoxygenation of the hypoxically injured heart. Verapamil significantly reduced the release of lactate dehydrogenase during reperfusion and reoxygenation of ischemic and hypoxic hearts, respectively. Maximal lactate dehydrogenase activities during reperfusion of the ischemic hearts, treated with verapamil, were 6.3 x 1.9 kat/g x ml/min, cornpared to activities obtained from untreated ischemic hearts, 23.6 + 5.4 kaVg x ml/min. Maximal lactate dehydrogenase activities during reoxygenation of the hypoxic hearts, treated with verapamil, were 3.6 x 0.9 kaVg x ml/min, compared to the activities of untreated hypoxic hearts, 8.0 x 2.4 kat/g x ml/min. Results of our experiment showed cytoprotective effects of verapamil, especially on local ischemic injury of the isolated heart.
Deskriptorji		CORONARY DISEASE VERAPAMIL HEART RATS MODELS, CARDIOVASCULAR LACTATE DEHYDROGENASE