Avtor/Urednik		Tratar, Gregor
Naslov		Ultrazvočne in magnetnoresonančne značilnosti krvnih strdkov in vpliv lokalnih hemodinamskih pogojev na raztapljanje strdkov s trombolitičnimi zdravili
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Univerza v Ljubljani, Medicinska fakulteta
Leto izdaje		2007
Obseg		str. 51
Jezik		slo
Abstrakt		Background. Even in contemporanv clinical practice thrombolvtic treatment plays an important role in management of vascazlar occlusions. The success of such treatment largely depends on characteristics of thrombus and thrombolytic agents. In our study we tested whether ultrasound (US) and mabnetic resonance imaging (MRI) uncover blood clot characteristics that influence the success of thrombolytic treatment. We also studied the influence of axially directed plasma flow alonb non occlusive clots on their dissolution with thrombolytic agents. Methods. The work consists of two studies. In the first study we examined 36 ex vivo pulmonary emboli (PE) by US and T1-weighted MRI and the results were compared with US and MRl images of model whole blood, plasma and thrombocyte-fibrin thrombi and platelet aggregates. We also compared MRI of PE and tumor emboli with immunohystochemical staining for platelets, erythrocytes and tumor cells. In the second study, we followed the penetration of paramagnetically labeled 0.9 sodium chloride into non occlusive clots on transverse and longitudinal sections in an in vitro model. We also followed penetration of paramagnetically labeled plasma into non occlusive retracted blood clots and dissolution of clots with rt-PA or streptokinase by T1-weighted MRI. Clots were exposed to axially directed saline or plasma flow of different velocities. Results. In the first study, we found that US signal was mainly influenced by retraction of clots. MRI, however, showed more structural details of PE. Areas of high-intensity MRI signal corresponded to areas containing either platelets or viable or necrotic tumor cells. In the second study penetration of 0.9% sodium chloride or plasma into non-occlusive clots was faster with rapid than with slow axially directed flow (5.2 vs. 42.5% on transverse sections and 3.4 vs. 46.9% on longitudinal sections, with slow or rapid flow respectively, all p < 0.05). (Abstract truncated at 2000 characters)
Deskriptorji		CLOT RETRACTION THROMBOLYTIC THERAPY MAGNETIC RESONANCE IMAGING PULMONARY EMBOLISM IMMUNOHISTOCHEMISTRY BLOOD PLATELETS ERYTHROCYTES