Avtor/Urednik		Stalowsky, Barbara; Vincek, Katarina; Kolšek, Mica
Naslov		Escherichia coli in okužbe sečil: občutljivost na antibiotike ter dejavniki tveganja za okužbo z odpornim sevi E. coli
Tip		monografija
Kraj izdaje		Ljubljana
Založnik		Medicinska fakulteta
Leto izdaje		2006
Obseg		str. 51
Jezik		slo
Abstrakt		Introduction: Urinary tract infections (UTl) are one of the most common bacterial infections. Escherichia coli, the main causative pathogen, accounts for approximately 80% of UTl isolates. Because the causative agent of UTI is highly predictable, antimicrobial therapy is often empiric. Drugs of choice currently used in the treatment of UTI are trimethoprim-sulfamethoxazole (TMP-SMX) and fluoroquinolones (most commonly ciprofloxacin). But according to several studies the resistance to these antibiotics is increasing and becoming a worldwide concern. Knowledge of risk factors predisposing to UTI with a resistant E.coli is so an important aid in selecting appropriate antimicrobial treatment. Aim: In this research we want to define more accurately which patients can still be treated empirically with TMPSMX or fluoroquinolones and those where an alternative antimicrobial treatment should be considered. I-Iypotesis: We wish to test the following hypothesis: (1) TMP-SMX can still be used empirically in treatment of community-acquired UTI in children and adults without additional risk factors; (2) ciprofloxacin can still be used empirically in treatment of community-acquired UTI in adults without additional risk factors; (3) in nosocomial UTI, UTI acquired in nursing homes and in patients with additional risk factors TMP-SMX and ciprofloksacin can no longer be used empirically. (Abstract truncated at 2000 characters)
Deskriptorji		URINARY TRACT INFECTIONS ESCHERICHIA COLI MICROBIAL SENSITIVITY TESTS CIPROFLOXACIN TRIMETHOPRIM DRUG RESISTANCE, MICROBIAL ANTIBIOTICS