Avtor/Urednik | Stanovnik, L; Logonder-Mlinšek, M; Erjavec, F | |
Naslov | A study of the role of histamine in gastric secretion in the isolated guinea pig gastric preparation | |
Tip | članek | |
Vir | Agents Actions | |
Leto izdaje | 1992 | |
Obseg | str. C372-5 | |
Jezik | eng | |
Abstrakt | Mast cell histamine could be involved in the regulation of gastric acid secretion. In order to compare the results on mast cell histamine obtained in experiments carried out on the isolated mouse stomach to guinea pig stomach, the method for isolated mouse stomach was adapted to isolated stomach wall of the guinea Pig. The modified preparation gave repeatable secretory responses to histamine and carbachol, similar to those in the isolated mouse stomach. Compound 48/80 (100 micro g/ml) did not evoke secretion, whereas a calcium ionophore, chlortetracycline (CTC), reduced basal secretion, as did low concentrations ( less th. 100 nmol/1) of histamine; chloropyramine (100 micro mol/1) counteracted the inhibitory effect of histamine. Histological examination of the guinea pig gastric mucosa showed more connective tissue mast cells (CTMC) than mucosal mast cells (MMC). CTMC were degranulated in response to chlortetracycline but not to compound 48/80. | |
Deskriptorji | HISTAMINE GASTRIC MUCOSA GASTRIC ACID GUINEA PIGS MAST CELLS CARBACHOL COMPOUND 48-80 CHLORTETRACYCLINE |