Avtor/Urednik     Stanovnik, L; Logonder-Mlinšek, M; Erjavec, F
Naslov     A study of the role of histamine in gastric secretion in the isolated guinea pig gastric preparation
Tip     članek
Vir     Agents Actions
Leto izdaje     1992
Obseg     str. C372-5
Jezik     eng
Abstrakt     Mast cell histamine could be involved in the regulation of gastric acid secretion. In order to compare the results on mast cell histamine obtained in experiments carried out on the isolated mouse stomach to guinea pig stomach, the method for isolated mouse stomach was adapted to isolated stomach wall of the guinea Pig. The modified preparation gave repeatable secretory responses to histamine and carbachol, similar to those in the isolated mouse stomach. Compound 48/80 (100 micro g/ml) did not evoke secretion, whereas a calcium ionophore, chlortetracycline (CTC), reduced basal secretion, as did low concentrations ( less th. 100 nmol/1) of histamine; chloropyramine (100 micro mol/1) counteracted the inhibitory effect of histamine. Histological examination of the guinea pig gastric mucosa showed more connective tissue mast cells (CTMC) than mucosal mast cells (MMC). CTMC were degranulated in response to chlortetracycline but not to compound 48/80.
Deskriptorji     HISTAMINE
GASTRIC MUCOSA
GASTRIC ACID
GUINEA PIGS
MAST CELLS
CARBACHOL
COMPOUND 48-80
CHLORTETRACYCLINE