Avtor/Urednik		Žitnik, SE
Naslov		Etiopatogenetski mehanizmi in klinične slike alergijskih bolezni
Prevedeni naslov		Ethyopathogenic mechanisms and clinical manifestations of allergic diseases
Tip		članek
Vir		Slov Pediatr
Vol. in št.		Letnik 14, št. 2
Leto izdaje		2007
Obseg		str. 75-9
Jezik		slo
Abstrakt		The incidence of allergic diseases has increased in the past few decades, and it is currently estimated that 30 of the population in the developed world has allergic disease. In the first years of life allergic children develop atopic dermatitis and have gastrointestinal problems. This is associated with hypersensibility to food allergens. After age three years children more often develop allergic rhinitis and asthma. Hypersensibility to inhalation allergens develops. A good understanding of the immunological and genetic mechanisms in the development of allergic diseases is the foundation for effective treatment and prevention of allergies. Numerous studies have shown that allergic diseases are a consequence of environmental and genetic factors. In the present paper immunological mechanisms and clinical manifestations of allergic diseases are presented.
Izvleček		Pojavljlanje alergijskih bolezni v zadnjih desetletjih narašča in zajame v razvitem svetu že blizu 30 % populacije. Pri otrocih z alergijami se v prvih lerih življenja pojavlja atopijski dermatitis in prebavne težave, kar je povezano predvsem s preobčutljivostjo na prehrambene alergene. Po tretjem letu starosti otroci pogosteje obolevajo zaradi alergijskega rinitisa in astme, senzibilizacija na prehrambene alergene ni več v ospredju. Pojavljati se začne preobčutljivostjo na inhalacijske alergene. Dobro razumevanje imunoloških ter genetskih mehanizmov razvoja bolezni je temelj učinkovitega zdravljenja in preprečevanja alergij. Številne študije dokazujejo, da so alergijske bolezni posledica vpliva dejavnikov iz okolja ob ustrezni genetski obremenitvi. V tem prispevku bodo predstavljeni imunološki mehanizmi alergijskih bolezni ter njihove klinične slike.
Deskriptorji		HYPERSENSITIVITY DERMATITIS, ATOPIC RHINITIS, ALLERGIC, PERENNIAL ASTHMA