Avtor/Urednik		Juhan-Vague, I; Alessi, MC; Mavri, A; Morange, PE
Naslov		Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
Tip		članek
Vir		J Thromb Haemost
Vol. in št.		Letnik 1, št. 7
Leto izdaje		2003
Obseg		str. 1575-9
Jezik		slv, eng
Abstrakt		Elevated plasma plasminogen activator inhibitor-1 (PAI-1) level is a core feature of insulin-resistance syndrome (IRS). Atherothrombotic complications in IRS are partly attributed to impaired fibrinolysis caused by increased plasma PAI-1 levels. Although the etiology of IRS is far from being explained, the clustering of inflammation, adipose tissue accumulation and insulin resistance suggests an etiopathological link. Proinflammatory cytokines might regulate PAI-1 expression in IRS; however, more studies are needed to confirm this complex mechanism in humans. Furthermore, modifying PAI-1 expression by PAI-1 inhibitors provides a new challenge and may reveal the true role of PAI-1 in atherosclerotic and insulin resistance processes.
Deskriptorji		INSULIN RESISTANCE ANIMALS HEART DISEASES OBESITY PLASMINOGEN ACTIVATOR INHIBITOR 1 RISK