Avtor/Urednik		Meden-Vrtovec, H; Vrtovec, B; Osredkar, J
Naslov		Metabolic and cardiovascular changes in women with polycystic ovary syndrome
Tip		članek
Vir		Int J Gynaecol Obstet
Vol. in št.		Letnik 99, št. 2
Leto izdaje		2007
Obseg		str. 87-90
Jezik		eng
Abstrakt		Objective: To analyze the relationship between QTc interval and cardiovascular risk factors in women with polycystic ovary syndrome (PCOS). Methods: Study group included 119 PCOS women (age: 32.2+/-5.2 years) and the control group 64 age-matched healthy women; they all underwent QT interval measurement, and plasma levels of high-sensitivity CRP (hsCRP), endothelin-1 (ET1), insulin, and testosterone determinations. Results: In PCOS women hsCRP (2.35+/-2.14 mg/L vs. 1.01+/-1.28 mg/L; P=0.04), ET1 (23.6+/-10.3 ng/L vs. 7.7+/-15.9 ng/L; P=0.01), and insulin (16.5+/-7.8 mIU/L vs. 11.8+/-10.7 mIU/L; P=0.03) levels were significantly higher, and QTc interval significantly shorter than in controls (401+/-61 ms vs. 467+/-61 ms; P=0.007). In 67 (56%) PCOS patients with a short QTc interval (<400 ms), plasma testosterone levels were significantly higher than in PCOS women with normal QTc interval (2.3+/-2.1 nmol/L vs. 1.4+/-1.7 nmol/L; P=0.02). Conclusion: In patients with polycystic ovary syndrome increased testosterone levels may attenuate the effects of coronary risk factors.
Deskriptorji		POLYCYSTIC OVARY SYNDROME ELECTROCARDIOGRAPHY C-REACTIVE PROTEIN ENDOTHELIN-1 INSULIN ADULT TESTOSTERONE CORONARY DISEASE RISK FACTORS