Avtor/Urednik		Osredkar, Joško
Naslov		Priporočila za uporabo biokemijskih označevalcev pri srčnem popuščanju
Prevedeni naslov		Recommendations on the use of biochemical markers in heart failure
Tip		članek
Vir		Slov Kardiol
Vol. in št.		Letnik 4, št. 2
Leto izdaje		2007
Obseg		str. 120-6
Jezik		slo
Abstrakt		The heart must be viewed as both a biological pump that cycles approximately 100,000 times per day and as an important hormone producing organ that produces biochemical signals that are antagonists for the sympathetic nervous system and the renin-angiotensin-aldosterone axis . Physiologically, there are a number of structurally and functionally related "heart hormones" manufactured by human cardiocytes. These include atrial natriuretic peptide (ANP), brain (or B-type) natriuretic peptide (BNP) and their respective N-terminal (NT) metabolic peptides termed NTANP and NT-proBNP. Release of the natriuretic peptides is stimulated by hemodynamic stress; these hormones have powerful diuretic, natriuretic, and vascular smooth muscle relaxing actions. Because of their central pathophysiological role in the cardiovascular system, the natriuretic peptides are elevated in conditions characterized by wall stretch, ventricular dilation and/or increased pressures resulting from excess fluid retention. Activation of the natriuretic system functions to reduce fluid blood volume and blood pressure.
Deskriptorji		HEART FAILURE, CONGESTIVE BIOLOGICAL MARKERS NATRIURETIC HORMONE VENTRICULAR DYSFUNCTION, LEFT PRACTICE GUIDELINES