Avtor/Urednik		Zimšek-Mijovski, Janet; Poljšak-Prijatelj, Mateja; Hočevar-Grom, Ada; Blaško, Mateja; Kovač, Katarina; Koren, Srečko
Naslov		Določanje in spremljanje molekularnoepidemioloških lastnosti izbruhov povzročenih s kalicivirusi v Sloveniji v letih 2000 do 2006
Prevedeni naslov		Detection and molecular epidemiology of calicivirus outbreaks in Slovene from 2000 to 2006
Tip		članek
Vir		Med Razgl
Vol. in št.		Letnik 46, št. Suppl 2
Leto izdaje		2007
Obseg		str. 75-81
Jezik		slo
Abstrakt		Human caliciviruses from the Caliciviridae family are the main cause of acute non-bacterial gastroenteritis in humans of all ages. They appear in both, epidemic and sporadic cases. Caliciviruses can not be propagated in cell cultures. Therefore, molecular methods for caliciviral detection, which represent the basis of molecular epidexniology, have been recently introduced. For studying molecular epidemiology of caliciviral outbreaks, were collected during the period from 2000 to 2006. Within a sample collection of 120 outbreaks, the caliciviral RNA regions coding for viral polymerase were analysed. In 2000, the first outbreaks caused by noroviruses from Caliciviridae family were detected. Almost one half of all outbreaks occured during the winter season, confirming wintertime seasonality of the desease. The highest frequency of outbreaks was observed in populations prone to caliciviral infection, i. e. those residing in semi-closed or closed environments, such as residential homes, day care centres, schools and hospitals. Few outbreaks were alimentary, i. e. caused by contaminated food in hotels and restaurants, or hydric, i. e. caused by contaminated drinking water. In the years 2002, 2005 and 2006, a significant rise in the number of outbreaks was noticed, probably due to emergence of a new viral strain with increased pathogenicity. The most frequently detected strain was GGIL4 genotype of the noroviral genogroup GGII. Genotypes from the GGI genogroup were detected rarely, although they caused a higher number of outbreaks in the years, with a lower total number of outbreaks. This confirms a hypothesis that the number of outbreaks depends on the predominance of a more virulent strain of noroviruses.
Deskriptorji		CALICIVIRIDAE INFECTIONS CALICIVIRIDAE DISEASE OUTBREAKS POLYMERASE CHAIN REACTION