Avtor/Urednik		Tomažič, Janez; Ul, Katja; Volčanšek, Gabriele; Gorenšek, Samo; Pfeifer, Miša; Kerner, Primož; Preželj, Janez; Vidmar, Gaj; Vidmar, Ludvik
Naslov		Prevalence and risk factors for osteopenia/osteoporosis in an HIV-infected male population
Tip		članek
Vir		Wien Klin Wochenschr
Vol. in št.		Letnik 119, št. 21-2
Leto izdaje		2007
Obseg		str. 639-46
Jezik		eng
Abstrakt		The objective of our investigation was to estimate the prevalence of osteopenia/osteoporosis in men with HIV/AIDS and evaluate the role of antiretroviral treatment (ART), HIV and other risk factors in reducing bone mineral density (BMD). All known Slovenian HIVinfected ART-naive and treated males (infected or treated > 12 months) were invited to participate in a cross-sectional study. Data were collected on age, BMI, waist-hip ratio, family history of hip fracture, duration of infection, duration of ART, smoking, alcohol, exercise, viral load and CD4+ cells. BMD was measured using dual X-ray absorptiometry. A total of 96 patients (out of 133 who fulfilled the inclusion criteria) were assessed and allocated into three groups: group A (n = 24), ART-naive; group B1 (n = 37), treated with non-protease-inhibitor (PI) containing ART; and group B2 (n = 35), treated with PIcontaining ART. The prevalence of osteopenia/osteoporosis was 57/96 (59%): osteopenia 45/96 (47%) and osteoporosis 12/96 (12%). Significantly lower BMD was detected in group A (P=0.020). Multiple logistic regression analysis showed ART to be an independent negative predictor for reduced BMD (P= 0.037; OR = 0.29, 95%CI 0.09-0.93). Vitamin D3 deficiency was detected in 79 (82%) of the patients. The study group represented 72% of the national HIV-infected male population; this proportion being higher than in any other study reported to date. The prevalence of reduced BMD was notably higher than the national prevalence among men of comparable age. There was no association between reduced BMD and any specific ART. According to our results, absence of ART was confirmed as an independent predictor of osteopenia/osteoporosis. Targeted screening and early treatment present a reasonable strategy for preventing reduced BMD in HIV-infected patients, but correcting vitamin D3 levels could also be an important component.
Deskriptorji		HIV INFECTIONS RISK FACTORS BONE DISEASES, METABOLIC OSTEOPOROSIS ANTI-HIV AGENTS BONE DENSITY HIP FRACTURES BODY MASS INDEX CROSS-SECTIONAL STUDIES