Avtor/Urednik		Penning, Trevor M; Jin, Yi; Lanišnik-Rižner, Tea; Bauman, David R
Naslov		Pre-receptor regulation of the androgen receptor
Tip		članek
Vir		Mol Cell Endocrinol
Vol. in št.		Letnik 281
Leto izdaje		2008
Obseg		str. 1-8
Jezik		eng
Abstrakt		The human androgen receptor (AR) is a ligand-activated nuclear transcription factor and mediates the induction of genes involved in the development of the male phenotype and male secondary sex characteristics, as well as the normal and abnormal growth of the prostate. We have identified the pair of bydroxysteroid dehydrogenases (HSDs) that regulate ligand access to the AR in human prostate. We find that type 3 3alpha-HSD (aldo-keto reductase (AKR)IC2) catalyzes the NADPH dependent reduction of the potent androgen Sa-dihydrotestosterone (5alpha-DHT) to yield the inactive androgen 3alpha-androstanediol (3alpha-diol). We also find that RoDH like 3alpha-HSD (RL-HSD) catalyzes the NAD+ dependent oxidation of 3alpha-diol to yield 5alpha-DHT. Together these enzymes are involved in the pre-receptor regulation of androgen action. Inhibition of AKR1C2 would be desirable in cases of androgen insufficiency and inhibition of RL-HSD might be desirable in benign prostatic hyperplasia.
Deskriptorji		PROSTATIC HYPERPLASIA PROSTATIC NEOPLASMS RECEPTORS, ANDROGEN HYDROXYSTEROID DEHYDROGENASES ANDROSTENEDIOLS KETONE OXIDOREDUCTASES