Avtor/Urednik | Ostojić, Saša; Volk, Marija; Medica, Igor; Kapović, Miljenko; Meden-Vrtovec, Helena; Peterlin, Borut | |
Naslov | Polymorphisms in the interleukin-12/18 genes and recurrent spontaneous abortion | |
Tip | članek | |
Vir | Am J Reprod Immunol | |
Vol. in št. | Letnik 58, št. 5 | |
Leto izdaje | 2007 | |
Obseg | str. 403-8 | |
Jezik | eng | |
Abstrakt | Problem: Interleukin (IL) IL-12/IL-18 are involved in uterine NK cells control of uterine vascular development. Polymorphisms in the IL-12/IL-18 genes could modify the cytokine balance, which might result in an increased susceptibility to recurrent spontaneous abortion (RSA). Method of study: A case-control study was conducted to determine the association between the IL12 (I/D) and IL18 (-607C>A, -137G>C) gene polymorphisms and the risk of RSA in 125 women with RSA and in 136 controls. Results: The frequencies of DD, ID, II for IL-12 were, 25.6%, 52.8% and 21.6% respectively, in patients versus 21.3%, 51.5% and 27.2% respectively in controls; the frequencies of CC, CA, AA genotypes for IL-18 (-607) were, 34.4%, 54.4% and 11.2% respectively in patients versus 30.1%, 58.1% and 11.8% respectively in controls; the frequencies of GG, GC, CC genotypes for IL-18(-137) were 47.2%, 43.2% and 9.6% respectively in patients and 45.6%, 46.3% and 8.1% respectively in controls. Conclusion: IL-12B and IL-18 promoter gene polymorphisms were not associated with RSA in our women. | |
Deskriptorji | ABORTION, HABITUAL ADULT CASE-CONTROL STUDIES DNA ELECTROPHORESIS, AGAR GEL GENOTYPE POLYMERASE CHAIN REACTION PREGNANCY VARIATION (GENETICS) |