| Avtor/Urednik | Ružič-Medvešček, Nadja | |
| Naslov | Povišana frekvenca srčnega utripa: neodvisen srčno-žilni dejavnik tveganja, nove možnosti znižanja | |
| Prevedeni naslov | High heart rate: independent cardiovascular risk factor, and new possibilities for its reduction | |
| Tip | članek | |
| Vir | Med Razgl | |
| Vol. in št. | Letnik 46, št. Suppl 1 | |
| Leto izdaje | 2007 | |
| Obseg | str. 129-33 | |
| Jezik | slo | |
| Abstrakt | Several epidemiologic and clinical studies have suggested a strong predictive power of high heart rate for cardiovascular morbidity and mortality. The association between heart rate and cardiovascular disease has been found in the general population, as well as in patients with myocardial infarction, chronic ischemic heart disease, heart failure, hypertension, and diabetes. Evidence from epidemiologic studies supports the important and independent role of heart rate as a risk factor for cardiovascular mortality, even after allowing for other well established cardiovascular risk factors. However, resting heart rate is not an established risk factor, because there are no prospective trials showing that therapeutic lowering of heart rate improves cardiovascular outcomes. Several drugs can be used to lower heart rate. Numerous controlled clinical trials have confirmed a highly significant effect of beta blockers on the total and cardiovascular mortality and sudden death in postmyocardial patients and in patients with cardiac systolic dysfunction or failure. A new drug, ivabradine is a pure heart rate lowering drug, devoid of any negative effect on myocardial contractility, coronary vasomotor tone, or on lipid and glucose metabolism. Ivabradine blocks If current and is a promising new therapeutic approach for coronary patients, as well as for other clinical disorders related to high heart rate. Ivabradine may be used in combination with beta blockers to minimise their adverse effects or instead of them in patients in whom beta blockers are contraindicated. | |
| Deskriptorji | HEART RATE TACHYCARDIA RISK FACTORS CORONARY DISEASE HYPERTENSION MYOCARDIAL INFARCTION HEART FAILURE, CONGESTIVE |