Avtor/Urednik		Rožman, P; Bolta, Z
Naslov		Use of platelet growth factors in treating wounds and soft-tissue injuries
Tip		članek
Vir		Acta Dermatovenerol Alp Panonica Adriat dosage/metabolism/*therapeutic use use
Vol. in št.		Letnik 16, št. 4
Leto izdaje		2007
Obseg		str. 156-65
Jezik		eng
Abstrakt		Tissue repair begins with clot formation and platelet degranulation, which release the growth factors (GFs) necessary for wound repair. Platelet-derived GFs are biologically active substances that enhance tissue repair mechanisms such as chemotaxis, cell proliferation, angiogenesis, extracellular matrix deposition, and remodeling. This review describes the biological background of the topical therapy of wounds and soft-tissue injuries with platelet gel (PG) and PG-derived GFs as well as the success of the clinical studies performed so far. Some other interesting topical applications of PG are also described. Platelet-derivatives represent a promising therapeutic modality, offering opportunities for treatment of wounds, ulcers, soft-tissue injuries, and various other applications in regenerative medicine.
Deskriptorji		BLOOD PLATELETS WOUND HEALING ANIMALS CYTOKINES PLATELET ACTIVATION PLATELET-DERIVED GROWTH FACTOR SKIN ULCER SOFT TISSUE INJURIES