Avtor/Urednik		Matos, Tadeja; Zver, Samo; Seme, Katja; Čižman, Milan; Ravnik, Janez
Naslov		Občutljivost gliv kvasovk, osamljenih iz nadzornih kužnin bolnikov s hematološkimi malignimi boleznimi v obdobju 1992-2005
Prevedeni naslov		Sensitivity of yeast isolated from surveillance specimens in patient with haematological malignancies in year 1992-2005
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 77, št. 2
Leto izdaje		2008
Obseg		str. 117-23
Jezik		slo
Abstrakt		Yeasts of the genus Candida are among the most, frequent causative agents of opportunistic infections. In the last decades, the increased incidence of fungal infections led to increased consumption of antifungal agents. Our study compared the sensitivity of Candida albicans and Candida glabrata isolated in two time periods 1992-1996and 2003-2005. The aim of our study was to determine whether the sensitivity of yeasts changed due to increased consumption of antifungal agents. All isolates were isolated from surveillance specimens of patients, hospitalized in the Department of Hematology, University Clinical Center Ljubljana. In all yeast isolates minimal inhibitory concentrations (MIC) of fluconazole, voriconazole, itraconazole and amphotericin B were determined using the E-test. Mann-Whitney's U test was used for statistical analysis. Statistical comparison generally indicated lower antifungal drug sensitivity of yeasts in years 1992-1996, in comparison to the period 2003-2005. MICs of all tested antifungal agents in C. albicans isolates were higher in years 1992-1996. Differences in MICs of itraconazole and voriconazole were observed in C. glabrata isolates. MIC.s of itraconazole were higher in years 1992-1996 and MICs of voriconazole were higher in years 20032005. However, no statistically significant differences in MICs of fluconazole and amphotericin B were observed. We have also studied the influence of antifungal prophylactic therapy on MIC.s of antifungal agents. For C. albicans the influence was shown for fluconazole and amphotericin B, while we could not show any influence for C. glabrata, most probably due to low member of is plates.
Deskriptorji		HEMATOLOGIC NEOPLASMS OPPORTUNISTIC INFECTIONS CANDIDIASIS CANDIDA MICROBIAL SENSITIVITY TESTS ANTIFUNGAL AGENTS FLUCONAZOLE AMPHOTERICIN B