Avtor/Urednik		Sinkovič, Andreja; Pahor, Artur
Naslov		Fulminant Wegener's granulomatosis with multiorgan dysfunction
Tip		članek
Vol. in št.		Letnik 3, št. 1
Leto izdaje		2008
Obseg		str. 119-22
Jezik		eng
Abstrakt		Fulminant cases of Wegener's granulomatosis (WG) with severe lung and kidney dysfunction may resemble pneumonia with sepsis and multiorgan dysfunction. Increased serum levels of antineutrophyl citoplasmic autoantibodies (c-ANCA) and proteinase 3 antibodies (PR3) confirm the correct diagnosis and are essential to start early immunosupressive treatment to improve the outcome. With the emphasis on diagnostic dilemmas, we present a 61-year old patient with fulminant WG, resembling pneumonia with sepsis and multiorgan dysfunction. After antibiotics and supportive measures increased serum levels of c-ANCA and PR3 confirmed the suspicion of WG and adequate immunosupressive treatment improved the patient's condition. We concluded that it is important to include vasculitis in the different diagnosis of unexplained multiorgan dysfunction, because only early adequate immunosupressive therapy in combination with other resuscitation measures improves survival.
Deskriptorji		VASCULITIS MULTIPLE ORGAN FAILURE PNEUMONIA SEPSIS IMMUNOSUPPRESSION RESPIRATORY INSUFFICIENCY TREATMENT OUTCOME SURVIVAL