Avtor/Urednik | Arnol, M; Starc, V; Knap, B; Potočnik, N; Bren, AF; Kandus, A | |
Naslov | Left ventricular mass is associated with ventricular repolarization heterogeneity one year after renal transplantation | |
Tip | članek | |
Vir | Am J Transplant | |
Vol. in št. | Letnik 8, št. 2 | |
Leto izdaje | 2008 | |
Obseg | str. 446-51 | |
Jezik | eng | |
Abstrakt | Ventricular repolarization heterogeneity (VRH) is associated with the risk of arrhythmia and cardiac death. This study investigated the association between VRH and left ventricular mass (LVM) in renal transplant recipients 1 year after transplantation. Echocardiography and 5-min 12-lead electrocardiogram were recorded and GFR was estimated (eGFR) in 68 nondiabetic patients. Beat-to-beat QT interval variability algorithm was used to calculate SDNN-QT and rMSSD-QT indices of VRH. To quantify QT interval variability relative to heart rate fluctuations, QTRR index was calculated. Left ventricular hypertrophy (LVH) was present in 44 patients (65%). LVM and incidence of LVH were increased in 28 patients with eGFR <60 mL/min/1.73 m(2) compared with 40 patients with eGFR > or =60 mL/min/1.73 m(2) (248 +/- 61 g and 86% vs. 210 +/- 46 g and 50%, respectively; p < 0.01). A direct correlation was found between LVM and SDNN-QT (R = 0.47, R(2)= 0.23; p < 0.001), rMSSD-QT (R = 0.27; R(2)= 0.10; p = 0.034), and QTRR (R = 0.55; R(2)= 0.31; p < 0.001) indices. In conclusion, greater LVM is associated with increased VRH in renal transplant recipients, providing a link with the high risk of arrhythmia and cardiac death, specifically in patients with decreased graft function. | |
Deskriptorji | KIDNEY TRANSPLANTATION ECHOCARDIOGRAPHY ARRHYTHMIA ELECTROCARDIOGRAPHY HYPERTROPHY, LEFT VENTRICULAR HEART ARREST |