Avtor/Urednik		Grat, Mateja; Jelenko, Tadeja; Vučković, Joško
Naslov		Fulminantni Epstein-Barr virusni hepatitis pri bolniku s kronično limfocitno levkemijo in okrnjeno imunsko odzivnostjo
Prevedeni naslov		Fulminant Epstein-Barr viral hepatitis in immunocompromised patient with chronic lymphocytic leukaemia
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 77, št. Suppl 1
Leto izdaje		2008
Obseg		str. I-157-9
Jezik		slo
Abstrakt		Backrgound Fulminant hepatitis with acute hepatic failure caused by Epstein-Barr virus (EBV) reactivation is rare and has high mortality. We report a case of fulminant EBV hepatitis with acute hepatic failure, disseminated intravascular coagulation and multiorgan failure in chronic lymphocytic leukaemia patient in relaps treated with alemtuzumab (monoclonal antiCD52) and standard chemoprophylaxis. After transient neutropenia he became icteric and had upper abdominal pain. The course was progressive and he died 13 days after onset of symptoms. We confirmed serologically and moleculary (EBV-DNA PCR) reactivation of EBV.