Avtor/Urednik | Hruškovičova, H; Dzurenkova, D; Selingerova, M; Bohus, B; Timkanicova, B; Kovacs, L | |
Naslov | The angiotensin converting enzyme I/D polymorphism in long distance runners | |
Tip | članek | |
Vir | J Sports Med Phys Fitness | |
Vol. in št. | Letnik 46, št. 3 | |
Leto izdaje | 2006 | |
Obseg | str. 509-13 | |
Jezik | eng | |
Abstrakt | Aim: There is an assumption that ACE I/D polymorphism represents one of the possible genetic factors that might be associated with sports excellence. Recent studies have identified an increased frequency of I allele in elite endurance athletes, long distance runners, rowers and mountaineers. The aim of this study was to test the hypothesis that the ACE I/D polymorphism is associated with enhanced endurance performance. Methods: We examined this hypothesis by determining ACE I/D allele frequency in 215 marathon runners, 222 half-marathon runners and 18 inline skaters classified by performance (marathon competition results). ACE genotype and allele frequencies were compared with 252 healthy controls. Results: ACE genotype frequency in the whole cohort did not differ from that in the sedentary controls (P < 0.56). However, there was an increase of the I/I genotype incidence amongst successful marathon runners scoring on places from 1st to 150th (P < 0.01). These findings were confirmed in the group of inline skaters, similarly demonstrating an increase of the I/I genotype (P < 0.01). There was no association found between half marathon runners and the ACE genotype (P < 0.59). Conclusions: An excess of the I allele in long distance runners confirms the association between the ACE I/D polymorphism and endurance sports performance. | |
Deskriptorji | RUNNING ADULT AGE DISTRIBUTION AGED ASPARTIC ACID CHILD GENE FREQUENCY GENOTYPE ISOLEUCINE LINEAR MODELS PEPTIDYL-DIPEPTIDASE A PHYSICAL ENDURANCE PREDICTIVE VALUE OF TESTS SKATING SLOVAKIA |