Avtor/Urednik		Zaletel, Marjan
Naslov		Neurovascular coupling during ageing and in migraneurs
Prevedeni naslov		Živčnožilna sklopitev pri starejših in bolnikih z migreno
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 77, št. Suppl 2
Leto izdaje		2008
Obseg		str. II-65-70
Jezik		eng
Abstrakt		A noninvasive assessment of neurovascular coupling using visually evoked cerebral blood flow velocity responses (VEFR) and visual evoked potentials (VEP), during normal ageing and in migraneurs, would be of great importance for interpretation of functional neuroimaging methods. According to the recent findings neurovascular coupling could be altered in older subjects and in migraneurs. The records were made from a group of healthy younger (37.5±9.4 years; 20 subjects) and older subjects (69.5±5.9 years; 20 subjects) as well as from patients with migraine (36.6 ± 10.4 years) interictally. The stimulus was a black-and-white checkerboard with visual contrasts of 1%, 10% and 100%. The VEFR were measured in the posterior cerebral artery using transcranial Doppler (TCD), and the VEP were recoded from occipital leads. To test the relationship between the VEFR, the VEP and the visual contrast, a linear regression analysis was performed. A significant increase of the VEFR and the VEP to graded visual contrasts (p < 0.01) was found both in the younger and older subjects. The linear regression showed a significant positive association between the VEP in the VEFR (r = 0.66, p < 0.01) of the younger and older subjects (r = 0.74, p < 0.01). The regression coefficient of the younger subjects was significantly higher (b = 0.54; SE = 0.07) than that of the older ones (b = 0.40; SE = 0.05) (p < 0.01). Also, we found an increase of VEFR and VEP within group of migraneurs (p < 0.01). VEFR were significantly higher in migraneurs (p < 0.01) compared to controls, while VEP did not significantly differ between the groups (p > 0.05). The regression showed a significant association between VEP and VEFR migraneurs (r = 0.63, p < 0.01). The regression coefficient of migraneurs (b = 0.88, SE = 0.08) was significantly higher than of healthy subjects (b = 0.55, SE = 0.07) (p = 0.04). (Abstract truncated at 2000 characters)
Izvleček		Neinvazivna analiza živčnožilne sklopitve z merjenjem evociranih možganskih odgovorov krvnega pretoka (VEOP) in vidnih evociranih potencialov (VEP) bi lahko bila pomembna zaradi razlage rezultatov funkcijskih slikovnih metod v zvezi s staranjem in pri bolnikih z migreno. V skladu s dosedanjimi spoznanji je živčnožilna sklopitev lahko spremenjena pri starejših in bolnikih z migreno. V raziskavi je sodelovalo20 zdravih mlajših (37,5 ± 9,4 leta) in 20 starejših preiskovancev (69,5 ± 5,9 leta) ter 30 bolnikov z migreno (36,6 ± 10,4 leta). Za svetlobni dražljaj smo uporabili šahovnico, na kateri smo spreminjali vidni kontrast. Uporabili smo 1-, 10- in 100-odstotni vidni kontrast. VEOP smo merili v zadnji možganski arteriji s transkranialnim Dopplerjem (TCD). VEP smo snemali v zatiljnih odvodih. VEOP in VEP so se pomembno povečali po draženju z različnim kontrastom (p < 0,01). Linearna regresija je pokazala statistično pomembno povezanost med VEOP in VEP pri starejših (r = 0,66, p < 0,01) in mlajših preiskovancih (r = 0,74, p < 0,01). Regresijski koeficient je bil pomembno večji pri mlajših (b = 0,54; SE = 0,07) kot pri starejših preiskovancih (b = 0,40; SE = 0,05) (p < 0,01). Ugotovili smo tudi pomembno povečanje VEOP in VEP v skupini bolnikov z migreno (p < 0,01). VEOP so bili pri bolnikih z migreno pomembno večji (p < 0,01), VEP pa se med skupinama niso pomembno razlikovali (p > 0,05). Regresija je pokazala pomembno povezanost med VEP in VEOP pri bolnikih z migreno (r = 0,63, p < 0,01). Regresijski koeficient je bil pri bolnikih z migreno (b = 0,88, SE = 0,08) pomembno večji kot kot pri zdravih preiskovancih (b = 0,55, SE = 0,07) (p = 0,04). Zaključili smo, da sočasno snemanje VEOP in VEP pri spreminjajočem se vidnem kontrastu kaže na zmanjšano živčnožilno sklopitev pri starejših bolnikih in povečano pri bolnikih z migreno v času brez migrenskega napada.
Deskriptorji		MIGRAINE ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL EVOKED POTENTIALS, VISUAL CEREBROVASCULAR CIRCULATION BLOOD FLOW VELOCITY AGING