| Avtor/Urednik | Kirbiš, Simon; Breskvar-Kač, Urška Dolores; Šabovič, Mišo; Zupan, Igor | |
| Naslov | Intracoronary and systemic levels of inflammation markers in patients with coronary artery disease | |
| Prevedeni naslov | Vpliv lokalnega vnetnega dogajanja na stabilnost aterosklerotičnih plakov | |
| Tip | članek | |
| Vir | Slov Kardiol | |
| Vol. in št. | Letnik 5, št. 1 | |
| Leto izdaje | 2008 | |
| Obseg | str. 16-21 | |
| Jezik | eng | |
| Abstrakt | Aim. Intracoronary and systemic plasma levels of circulating markers of (vascular) inflammation were compared in order to determine the role of local and systemic origin of inflammation in patients with coronary artery disease. Patients and methods. Patients with acute coronary syndrome (ACS) (N=11) and stable angina pectoris (N=10), and controls (N=9) were included in the study. Intracoronary blood samples were taken at the culprit lesion and the unaffected left or right coronary artery from patients with ACS, and from the left and right coronary artery in other two groups. Systemic blood samples were taken from the femoral vein and femoral artery. High sensitivity C reactive protein (hsCRP), interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), soluble receptor for interleukin 2 (tR IL-2) and myeloperoxidase (MPO) were measured in all obtained blood samples. Results. No difference was found between intracoronary and systemic levels of all inflammatory markers in ACS patients and in patients with stable angina. Importantly, no difference was detected when the levels of inflammatory markers at the culprit lesion were compared to those from an unaffected coronary artery in patients with ACS. However, patients with ACS had significantly elevated (intracoronary and systemic) levels of hsCRP and IL-10 compared to those with stable angina and controls. No difference in any marker existed between patients with stable angina and controls. Conclusion. Our results strongly suggest that systemic rather than local vascular inflammation is crucial for the increased inflammation state present in patients with CAD, particularly patients with ACS. | |
| Deskriptorji | CORONARY DISEASE INFLAMMATION MEDIATORS ATHEROSCLEROSIS CORONARY ANGIOGRAPHY CORONARY VESSELS FEMORAL ARTERY FEMORAL VEIN |