Avtor/Urednik		De Boeck, Bart; Kirn, Borut; Teske, Arco J; Hummeling, Ralph W; Doevendans, Pieter A; Cramer, Maarten J; Prinzen, Frits W
Naslov		Three-dimensional mapping of mechanical activation patterns, contractile dyssynchrony and dyscoordination by two-dimensional strain echocardiography: rationale and design of a novel software toolbox
Tip		članek
Vir		Cardiovasc Ultrasound
Vol. in št.		Letnik 6
Leto izdaje		2008
Obseg		str. 22 (1-12)
Jezik		eng
Abstrakt		Background: Dyssynchrony of myocardial deformation is usually described in terms of variability only (e.g. standard deviations SD's). A description in terms of the spatio-temporal distribution pattern (vector-analysis) of dyssynchrony or by indices estimating its impact by expressing dyscoordination of shortening in relation to the global ventricular shortening may be preferential. Strain echocardiography by speckle tracking is a new non-invasive, albeit 2-D imaging modality to study myocardial deformation. Methods: A post-processing toolbox was designed to incorporate local, speckle tracking-derived deformation data into a 36 segment 3-D model of the left ventricle. Global left ventricular shortening, standard deviations and vectors of timing of shortening were calculated. The impact of dyssynchrony was estimated by comparing the end-systolic values with either early peak values only (early shortening reserve ESR) or with all peak values (virtual shortening reserve VSR), and by the internal strain fraction (ISF) expressing dyscoordination as the fraction of deformation lost internally due to simultaneous shortening and stretching. These dyssynchrony parameters were compared in 8 volunteers (NL), 8 patients with Wolff-Parkinson-White syndrome (WPW), and 7 patients before (LBBB) and after cardiac resynchronization therapy (CRT). Results: Dyssynchrony indices merely based on variability failed to detect differences between WPW and NL and failed to demonstrate the effect of CRT. Only the 3-D vector of onset of shortening could distinguish WPW from NL, while at peak shortening and by VSR, ESR and ISF no differences were found. All tested dyssynchrony parameters yielded higher values in LBBB compared to both NL and WPW. CRT reduced the spatial divergence of shortening (both vector magnitude and direction), and improved global ventricular shortening along with reductions in ESR and dyscoordination of shortening expressed by ISF. (Abstract truncated at 2000 characters)
Deskriptorji		IMAGE INTERPRETATION, COMPUTER-ASSISTED ADULT AGED BUNDLE-BRANCH BLOCK CARDIAC PACING, ARTIFICIAL CASE-CONTROL STUDIES ECHOCARDIOGRAPHY ECHOCARDIOGRAPHY, THREE-DIMENSIONAL ELECTROCARDIOGRAPHY EQUIPMENT DESIGN EQUIPMENT SAFETY GATED BLOOD-POOL IMAGING MYOCARDIAL CONTRACTION NETHERLANDS PROBABILITY SENSITIVITY AND SPECIFICITY WOLFF-PARKINSON-WHITE SYNDROME