Avtor/Urednik		Thangarajh, Mathula; Masterman, Thomas; Helgeland, Lars; Rot, Uroš; Jonsson, Malin V; Egil-Eide, Geir; Pirskanen, Ritva; Hillert, Jan; Jonsson, Roland
Naslov		The thymus is a source of B-cell-survival factors-APRIL and BAFF-in myasthenia gravis
Tip		članek
Vir		J Neuroimmunol Suppl
Vol. in št.		Letnik 178, št. 1-2
Leto izdaje		2006
Obseg		str. 161-6
Jezik		eng
Abstrakt		The accumulation of B cells in the thymus is a common feature of myasthenia gravis (MG). To understand whether factors enhancing B-cell survival are increased in MG, we studied the expression of APRIL, BAFF and three of their receptors in the thymus. In hyperplastic thymi, macrophages expressed APRIL and BAFF, and germinal-center B cells, BAFF-R. CD138-positive plasma cells were abundant in MG thymi. By contrast, BCMA-positive plasma cells were scarce. The expression of APRIL and BAFF in MG thymi may reflect the establishment of an environment favorable to B-cell survival.
Deskriptorji		ADULT AGED AGED, 80 AND OVER B-LYMPHOCYTES ENZYME-LINKED IMMUNOSORBENT ASSAY IMMUNOHISTOCHEMISTRY MEMBRANE GLYCOPROTEINS MEMBRANE PROTEINS MYASTHENIA GRAVIS PROTEOGLYCANS RECEPTORS, TUMOR NECROSIS FACTOR THYMUS GLAND