Avtor/Urednik		Šmuc, Tina; Ribič-Pucelj, Martina; Lanišnik-Rižner, Tea
Naslov		Molekularne osnove patogeneze endometrioze
Prevedeni naslov		Molecular basis of endometriosis
Tip		članek
Vir		Zdrav Vestn
Vol. in št.		Letnik 77, št. 8
Leto izdaje		2008
Obseg		str. 515-8
Jezik		slo
Abstrakt		Endometriosis is defined as the presence of endometrial glands and stroma within extrauterine sites. Estimations show that up to 15 % of women in their reproductive age are affected Extrauterine endometrial tissue can be found on the pelvic peritoneum, on the ovaries, in the rectovaginal septum, and more rarely, in the pericardium and pleura forming three different entities: peritoneal endometriosis, ovarian endometriosis and deep endometriotic nodules of the rectovaginal septum. Symptoms for endometriosis may include painful and/ or heavy periods, pain during intercourse, pelvic pain, 30-50 % reduced fertility, and low back pain. Pathogenesis of endometriosis is not yet fully understood. It is well known that endometriosis is an estrogen-dependent disease, with distinctive genetic, immunological and enviromental risk factors. The review focuses on different cell processes which are disturbed in endometriosis patients. A better understanding of the molecular basis of endometriosis will aid in identification of molecular markers and novel drug targets in the future, providing better diagnostics and treatment.
Deskriptorji		ENDOMETRIOSIS CELL ADHESION EXTRACELLULAR MATRIX NEOVASCULARIZATION, PATHOLOGIC INFLAMMATION ESTRADIOL